{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:24:40Z","timestamp":1770816280631,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The aim of this study was to evaluate the remineralization effect of NaF, NaF with TCP, NaF with CPP\u2010ACP and NaF with CXP varnishes on newly erupted first permanent molars using laser fluorescence (LF) method. The study was a randomized, double\u2010blind, controlled trial with four parallel groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was carried out in 48 high caries\u2010risk children (DMFS &gt;8), aged 6\u20137\u2009years with newly erupted permanent first molars (initial lesion with 13\u2009&lt;\u2009LF value&lt;30). A total of 140 teeth were divided randomly into four groups (<jats:italic>n<\/jats:italic>\u2009=\u200935): <jats:bold>G1.<\/jats:bold>Duraphat Varnish containing 5% NaF, <jats:bold>G2.<\/jats:bold> Clinpro\u2122 White Varnish containing 5% NaF with TCP, <jats:bold>G3.<\/jats:bold>Embrace\u2122 Varnish containing 5% NaF with CXP, <jats:bold>G4.<\/jats:bold> MI Varnish containing 5% NaF with CPP\u2010ACP. All dental treatments of the patients were completed before the varnish application. The varnishes were applied to the targeted teeth at baseline, 1 and 3\u2009months. Patients were called for follow\u2010up appointments at 1, 3 and 6\u2009months, and LF scanning was used to monitor mineralization changes. Data were analysed statistically by Wilcoxon signed\u2010rank and Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 40 children (122 teeth) completed the trial. At the end of 6\u2009months, the amount of reduction in LF values (indicating remineralization) are as follows: NaF with CXP(6.87\u2009\u00b1\u20094.32)\u2009&lt;\u2009NaF with TCP(7.36\u2009\u00b1\u20097.05)\u2009&lt;\u2009NaF(7.40\u2009\u00b1\u20097.03)\u2009&lt;\u2009NaF with CPP\u2010ACP(8.33\u2009\u00b1\u20094.90). All of the varnishes resulted in significant decrease in LF measurements and there was no significant difference between control (NaF alone) group and other groups. Only MI varnish had a significantly greater remineralization effect than Embrace\u2122 Varnish (<jats:italic>p\u2009&lt;<\/jats:italic>\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As a non\u2010invasive approach, CPP\u2010ACP, TCP and CXP containing NaF varnishes have the potential to remineralize initial caries lesions on permanent first molars in high caries\u2010risk children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/idh.12778","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T16:33:33Z","timestamp":1697214813000},"page":"703-710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Remineralization effect of <scp>NaF<\/scp>, <scp>NaF<\/scp> with <scp>TCP<\/scp>, <scp>NaF<\/scp> with <scp>CPP\u2010ACP<\/scp> and <scp>NaF<\/scp> with <scp>CXP<\/scp> varnishes on newly erupted first permanent molars: A randomized controlled trial"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6766-2023","authenticated-orcid":false,"given":"Merve","family":"Erkmen Almaz","sequence":"first","affiliation":[{"name":"K\u0131r\u0131kkale University  K\u0131r\u0131kkale Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nur Burcu","family":"Ulusoy","sequence":"additional","affiliation":[{"name":"Private practice  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aylin","family":"Akbay\u00a0Oba","sequence":"additional","affiliation":[{"name":"Private practice  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysun","family":"Dokumac\u0131","sequence":"additional","affiliation":[{"name":"Private practice  Ankara 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