{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:44:14Z","timestamp":1778705054594,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010558","name":"Beiersdorf","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010558","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cheilitis is a chronic inflammatory condition of the lips, and frequent or prolonged use of topical corticosteroids may lead to various adverse events. Therefore, alternative therapies with fewer side effects are beneficial for the treatment of this condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the efficacy of a lip care formulation containing both panthenol and bisabolol as a monotherapy for mild\u2010to\u2010moderate cheilitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010centre prospective pilot open\u2010label study included 20 patients with mild\u2010to\u2010moderate cheilitis who were treated with the tested lip care for 8\u2009weeks and evaluated by physician and patient assessments before the final efficacy was determined using the Visioscan score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 20 patients, 13 (65.0%) presented with moderate cheilitis with dry and chapped lips. All parameters, including physician and patient clinical scores and bioengineering measurements, showed significant improvements as early as week 2 and sustained until week 8 following the application of the tested lip care. The frequency of cheilitis flareups also decreased significantly. The tested product was well tolerated without any adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lip care with panthenol and bisabolol was safe and effective. It can be used as monotherapy for the treatment of mild\u2010to\u2010moderate cheilitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/idh.12779","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T06:25:26Z","timestamp":1698215126000},"page":"711-716","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of panthenol\u2010 and bisabolol\u2010containing lip care as monotherapy for mild\u2010to\u2010moderate cheilitis"],"prefix":"10.1111","volume":"22","author":[{"given":"Supenya","family":"Varothai","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pichanee","family":"Chaweekulrat","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chutipon","family":"Pruksaeakanan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supisara","family":"Wongdama","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waranya","family":"Boonchai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,24]]},"reference":[{"issue":"2","key":"e_1_2_12_2_1","first-page":"342","article-title":"Differential diagnosis of cheilitis \u2013 how to classify cheilitis?","volume":"57","author":"Lugovic\u2010Mihic L","year":"2018","journal-title":"Acta Clin Croat"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.142483"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12351"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12499"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13531"},{"issue":"2","key":"e_1_2_12_7_1","first-page":"91","article-title":"Moisturizers for patients with atopic dermatitis","volume":"31","author":"Varothai S","year":"2013","journal-title":"Asian Pac J Allergy Immunol"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2015.1086477"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05741.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200203060-00005"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2017.1325310"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2016.1218417"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2016.1214235"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2010.09072"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389201015666140528152946"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0026-4946.17.05015-0"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01225.x"}],"container-title":["International Journal of Dental Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/idh.12779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T08:24:52Z","timestamp":1721636692000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/idh.12779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,24]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/idh.12779"],"URL":"https:\/\/doi.org\/10.1111\/idh.12779","archive":["Portico"],"relation":{},"ISSN":["1601-5029","1601-5037"],"issn-type":[{"value":"1601-5029","type":"print"},{"value":"1601-5037","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,24]]},"assertion":[{"value":"2022-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}