{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T05:48:42Z","timestamp":1772689722204,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T00:00:00Z","timestamp":1705276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The present study aimed to assess and compare the effect of <jats:italic>Morus alba<\/jats:italic> and chlorhexidine gel as an adjunct to scaling and root planing (SRP) in treating stage II periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010blind, randomized controlled trial was conducted on 180 patients with stage II periodontitis who received full\u2010mouth SRP. They were randomly assigned to receive chlorhexidine digluconate (CHX) gel, <jats:italic>Morus alba<\/jats:italic> (MA) and placebo gel for Groups A, B and C, respectively, at the baseline, 15\u2009days and 30\u2009days. Plaque index (PI), Gingival index (GI), periodontal pocket depth (PPD) and quantitative analysis (culture) of <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic>, <jats:italic>Porphyromonas gingivalis<\/jats:italic> and <jats:italic>Tannerella forsythia<\/jats:italic> were assessed at baseline and 45\u2009days. Analysis of variance was used to compare the significant difference in PI, GI, PPD and microbiological parameters between the three groups after the intervention, followed by post hoc Mann\u2013Whitney <jats:italic>U<\/jats:italic> and Tukey's HSD test for clinical and microbiological parameters, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intergroup comparison of the PI, GI and microbiological parameters between the MA and CHX groups at the end of 45\u2009days did not show a statistically significant difference (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05), whereas a statistically significant difference was observed for PPD between MA and CHX groups with the mean difference of 0.18\u2009mm (<jats:italic>p<\/jats:italic>\u2009=\u20090.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>Morus alba<\/jats:italic> gel was found to be effective in decreasing PPD. However, there was no difference between Morus alba and chlorhexidine gel as an adjunct to SRP in treating stage II periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/idh.12781","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T07:29:30Z","timestamp":1705390170000},"page":"717-726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of the effectiveness of <i>Morus alba<\/i> and chlorhexidine gels as an adjunct to scaling and root planing on stage <scp>II<\/scp> periodontitis \u2013 A randomized controlled clinical trial"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2533-996X","authenticated-orcid":false,"given":"Shilpa","family":"Gunjal","sequence":"first","affiliation":[{"name":"Division of Clinical Oral Health Sciences, School of Dentistry International Medical University  Kuala Lumpur 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