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Patients were instructed to use the mouthwash after instrumentation for twice a day up to 3\u2009weeks. Periodontal parameters such as probing pocket depth (PPD), clinical attachment loss (CAL), O'Leary plaque index (PI), Loe and Silness gingival index (GI), Lobene stain index (SI), and oral soft tissue changes were recorded at baseline and once every week for 3\u2009weeks. The visual analogue scale (VAS) was also recorded as a self\u2010administered questionnaire at the end of the study. The one\u2010way ANOVA was used to compare VAS scores between the groups. The repeated measures ANOVA and post hoc Newman\u2013Keuls tests were used to assess the differences in the periodontal parameters between groups at different time intervals. The Kruskal\u2013Wallis test was used to compare the mean SI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant reduction in the mean GI of the OCT and CHX groups compared to placebo (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). OCT usage resulted in significantly less staining, according to mean SI, when compared to CHX. Furthermore, VAS scores revealed that OCT was significantly the preferred mouthwash (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adjunctive octenidine hydrochloride may be an alternative to chlorhexidine in its ability to control the periodontal parameters in patients with stage I\u2013II periodontitis. Further larger studies are necessary to confirm these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/idh.12795","type":"journal-article","created":{"date-parts":[[2024,3,10]],"date-time":"2024-03-10T14:34:25Z","timestamp":1710081265000},"page":"802-813","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of adjunctive octenidine hydrochloride as compared to chlorhexidine and placebo as adjuncts to instrumentation in stage <scp>I\u2013II<\/scp> periodontitis: A double\u2010blinded randomized controlled trial"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5151-0794","authenticated-orcid":false,"given":"Avita","family":"Rath","sequence":"first","affiliation":[{"name":"Faculty of Dentistry SEGi University  Petaling Jaya Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Wong","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry SEGi University  Petaling Jaya Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keehon","family":"Li","sequence":"additional","affiliation":[{"name":"Ministry of Health  Putrajaya Wilayah Perseketuan Putrajaya Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Wong","sequence":"additional","affiliation":[{"name":"Ministry of Health  Putrajaya Wilayah Perseketuan Putrajaya Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Tan","sequence":"additional","affiliation":[{"name":"Ministry of Health  Putrajaya Wilayah Perseketuan Putrajaya Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Tan","sequence":"additional","affiliation":[{"name":"Ministry of Health  Putrajaya Wilayah Perseketuan Putrajaya Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio Mendes","family":"Pannuti","sequence":"additional","affiliation":[{"name":"Department of Stomatology University of Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,10]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","first-page":"44","article-title":"Periodontal disease and COVID\u201019: prognosis and potential pathways of association in their pathogenesis","volume":"57","author":"Carmona Loayza DA","year":"2023","journal-title":"Can J Dent Hyg"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12362"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14102174"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10122413"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13275"},{"key":"e_1_2_11_7_1","volume-title":"Role of the Mechanical Interdental Plaque Control in the Management of Periodontal Health: How Many Options do we Have? 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