{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:08:19Z","timestamp":1773032899044,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Gingivitis is a common inflammatory lesion caused by the build\u2010up of oral biofilm and is an essential precursor to periodontitis. For its treatment, oral hygiene habits, such as dental flossing, must be improved, and adjunctive materials, such as hyaluronic acid, may be used to reduce plaque formation and gingival inflammation. This study aimed to assess the effects of 0.2% hyaluronic acid gel\u2010impregnated dental floss on the clinical periodontal markers of patients with gingivitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>This clinical study adopted a split\u2010mouth, randomised controlled trial design. After clinical data were assessed at baseline, and supragingival scaling was performed, bilateral gingivitis regions were randomly allocated to either the hyaluronic acid gel\u2010impregnated floss group or just the floss group using a computer\u2010generated randomisation table. Clinical parameters were recorded at 1, 2 and 4\u2009weeks after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over the 4\u2010week trial period, all patients showed significant improvements in all clinical periodontal markers. The 1\u2010week plaque index, 4\u2010week gingival index and 4\u2010week papillary bleeding index were significantly lower in the test group than in the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The use of hyaluronic acid\u2010impregnated dental floss has resulted in more significant improvements in clinical periodontal parameters compared to dental floss alone. For ease of use, ready\u2010made products with this innovative formulation may be produced.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT06307041\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/idh.12856","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T01:21:36Z","timestamp":1730251296000},"page":"312-318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of 0.2% Hyaluronic Acid Gel\u2010Impregnated Dental Floss on Clinical Gingival Parameters: A Randomised Clinical Trial"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2964-8244","authenticated-orcid":false,"given":"\u00d6zlem Sara\u00e7","family":"Atag\u00fcn","sequence":"first","affiliation":[{"name":"Department of Periodontology, G\u00fclhane Faculty of Dentistry University of Health Sciences  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3286-7819","authenticated-orcid":false,"given":"Seval Ceylan","family":"\u015een","sequence":"additional","affiliation":[{"name":"Department of Periodontology, G\u00fclhane Faculty of Dentistry University of Health Sciences  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4205-861X","authenticated-orcid":false,"given":"G\u00fclbahar","family":"Ustao\u011flu","sequence":"additional","affiliation":[{"name":"Department of Periodontology, G\u00fclhane Faculty of Dentistry University of Health Sciences  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5633-9359","authenticated-orcid":false,"given":"Erkan","family":"\u00d6zcan","sequence":"additional","affiliation":[{"name":"Department of Periodontology, G\u00fclhane Faculty of Dentistry University of Health Sciences  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12688"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0095"},{"issue":"4","key":"e_1_2_10_4_1","article-title":"Home Use of Interdental Cleaning Devices, in Addition to Toothbrushing, for Preventing and Controlling Periodontal Diseases and Dental Caries","volume":"4","author":"Worthington H. 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