{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:03:04Z","timestamp":1787842984281,"version":"build-2784847793"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T00:00:00Z","timestamp":1731801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T00:00:00Z","timestamp":1731801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2025,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n Children and young patients with chronic kidney disease (CKD) are at persistent risk of gingivitis despite usual preventive measures. This clinical study aimed to determine the efficacy of an intensive oral preventive programme (OPP) for young patients with CKD in treating plaque\u2010induced gingivitis modified by systemic factors.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Young patients with CKD (\n N<\/jats:italic>\n \u2009=\u200930) were recruited\/randomised to a need\u2010related OPP (\n n<\/jats:italic>\n \u2009=\u200915) or treatment as usual (TAU) including mainly motivation and instructions (controls,\n n<\/jats:italic>\n \u2009=\u200915) followed by a single intensive prophylactic appointment after 3\u2009months. For the OPP group, depending on the baseline degree of inflammation (PBI) professional mechanical plaque removal, local chlorhexidine gel application and mouth rinse were applied at need\u2010related appointments focussing on local plaque control and reduction in inflammation.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n After 3\u2009months OPP, lower plaque indices were found (2.62\u20130.66,\n p<\/jats:italic>\n \u2009<\u20090.05) in contrast to TAU (2.32\u20132.05,\n p<\/jats:italic>\n \u2009>\u20090.05) with differences between study groups (\n p<\/jats:italic>\n \u2009<\u20090.05). Regarding gingivitis, lower PBI values than baseline were observed in OPP (1.03\u20130.05,\n p<\/jats:italic>\n \u2009<\u20090.05) than TAU (1.15\u20131.00;\n p<\/jats:italic>\n \u2009>\u20090.05); OPP reductions (effect size) were higher than after a single intensive appointment (1.00\u20130.36;\n p<\/jats:italic>\n \u2009<\u20090.05). Degree of immunosuppressive therapy did not differ between groups throughout the study.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Young patients with CKD suffer from generalised gingivitis with increased bleeding sites. This moderate degree of inflammation shows a normal distribution of high and low plaque responders, with no pattern of impact for the degree of immunosuppression. Effectiveness and duration of preventive measures follow a dose\u2013response principle. Therefore, need\u2010related preventive measures should be implemented and maintained in future regular care for CKD patients.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n German Clinical Trials Register, registration number: DRKS00010580<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/idh.12866","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T01:49:00Z","timestamp":1731894540000},"page":"362-373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Gingivitis Control in Children, Adolescents and Young Adults With Chronic Kidney Disease by a Need\u2010Related Programme: A Randomised Clinical Trial"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8284-9849","authenticated-orcid":false,"given":"Karolin C.","family":"H\u00f6fer","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University Hospital Cologne, Polyclinic for Operative Dentistry and Periodontology University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Witte","family":"Hanna","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University Hospital Cologne, Polyclinic for Operative Dentistry and Periodontology University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9598-8861","authenticated-orcid":false,"given":"Graf","family":"Isabelle","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Medicine, University Hospital Cologne University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2571-5590","authenticated-orcid":false,"given":"Golka","family":"Anna","sequence":"additional","affiliation":[{"name":"Paediatric Nephrology, Children's and Adolescents' Hospital, University Hospital of Cologne, Faculty of Medicine University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3286-1131","authenticated-orcid":false,"given":"Adams","family":"Anne","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics and Computational Biology (IMSB), Medical Faculty University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0169-2582","authenticated-orcid":false,"given":"Anna Greta","family":"Barbe","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University Hospital Cologne, Polyclinic for Operative Dentistry and Periodontology University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4116-598X","authenticated-orcid":false,"given":"Lutz Thorsten","family":"Weber","sequence":"additional","affiliation":[{"name":"Paediatric Nephrology, Children's and Adolescents' Hospital, University Hospital of Cologne, Faculty of Medicine University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5303-4616","authenticated-orcid":false,"given":"Michael J.","family":"Noack","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University Hospital Cologne, Polyclinic for Operative Dentistry and Periodontology University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467\u2010002\u20100999\u20107"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2005.00812.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12993"},{"issue":"3","key":"e_1_2_9_5_1","first-page":"235","article-title":"Oral Health and Pro\u2010Inflammatory Status in End\u2010Stage Renal Disease Patients","volume":"5","author":"Buhlin K.","year":"2007","journal-title":"Oral Health & Preventive Dentistry"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jper.17\u20100095"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467\u2010020\u201004913\u20109"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf00865474"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2007.01173.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12382"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12366"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12502"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13957"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12280"},{"issue":"2","key":"e_1_2_9_15_1","first-page":"96","article-title":"Odontogenic Bacteremia Following Tooth Cleaning Procedures in Children","volume":"22","author":"Lucas V.","year":"2000","journal-title":"Pediatric Dentistry"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007447.pub2"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1974.tb01248.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886\u2010021\u201001559\u20103"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523\u20101755.2005.00602.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis823"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1986.tb00881.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.2004.00478.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.17219\/dmp\/81747"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050061"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010022\u201002670\u20109"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2012.01883.x"},{"issue":"2","key":"e_1_2_9_27_1","first-page":"108","article-title":"The Oral Health Status of Children Undergoing Hemodialysis Treatment","volume":"45","author":"Ertu\u011frul F.","year":"2003","journal-title":"Turkish Journal of Pediatrics"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201041207\u2010z"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201069931\u2010x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12039"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.184754"}],"container-title":["International Journal of Dental Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/idh.12866","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/idh.12866","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/idh.12866","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:19:09Z","timestamp":1773029949000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/idh.12866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,17]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/idh.12866"],"URL":"https:\/\/doi.org\/10.1111\/idh.12866","archive":["Portico"],"relation":{},"ISSN":["1601-5029","1601-5037"],"issn-type":[{"value":"1601-5029","type":"print"},{"value":"1601-5037","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,17]]},"assertion":[{"value":"2022-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}