{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:05:29Z","timestamp":1755907529164,"version":"3.44.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy of subgingival erythritol powder air polishing (EPAP) for inducing initial healing of shallow\u2010to\u2010moderate periodontal pockets and its effect on gingival crevicular fluid (GCF) \u03b2\u2010catenin, 8\u2010hydroxy\u2010deoxyguanosine (8\u2010OHdG) and total antioxidant capacity (TAC) levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomised, split\u2010mouth clinical trial involved 22 periodontitis patients. Periodontal pockets (4\u20136\u2009mm) were treated either by scaling and root planing (control) or EPAP followed by subgingival instrumentation 1\u2009month later (test). Clinical periodontal variables were recorded, and GCF samples were collected from the selected sites at baseline, week 4 and week 12 visits. The GCF levels of \u03b2\u2010catenin, 8\u2010OHdG and TAC were estimated via enzyme\u2010linked immunosorbent assay (ELISA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with those at baseline, both groups showed non\u2010different significant reductions in clinical variables at week 4 and week 12 after treatment. GCF \u03b2\u2010catenin and 8\u2010OHdG levels at both the test and control sites significantly decreased at week 4 and continued to further decrease at week 12. A greater reduction in GCF \u03b2\u2010catenin was detected at the control sites at the week 12 visit. Conversely, GCF TAC was only significantly increased at week 12 in both groups, but the difference between the groups was not significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Using of EPAP has the potential to induce initial healing in shallow\u2010to\u2010moderate pockets as it offers non\u2010different changes in clinical outcomes and GCF biomarkers compared to conventional method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> identifier: NCT05798871<\/jats:p><\/jats:sec>","DOI":"10.1111\/idh.12887","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T03:51:39Z","timestamp":1734407499000},"page":"559-569","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Erythritol Air Polishing for Inducing Initial Healing of Shallow\u2010to\u2010Moderate Periodontal Pockets and Restoring Gingival Crevicular Fluid \u03b2\u2010Catenin, 8\u2010Hydroxy\u2010Deoxyguanosine and Total Antioxidant Capacity: A Split\u2010Mouth Randomised Clinical Trial"],"prefix":"10.1111","volume":"23","author":[{"given":"Muhsin","family":"Aljaberi","sequence":"first","affiliation":[{"name":"Department of Periodontics, College of Dentistry University of Baghdad  Baghdad Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0606-2830","authenticated-orcid":false,"given":"Hayder Raad","family":"Abdulbaqi","sequence":"additional","affiliation":[{"name":"Department of Periodontics, College of Dentistry University of Baghdad  Baghdad Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12153"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.26477\/jbcd.v34i4.3272"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.1103"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12342"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2006.01029.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120195"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.13125"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/567305"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2019.7794"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03\u20100351"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.001247"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u2010051X.29.s3.4.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u2010051X.29.s2.4.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp\u2010journals\u201010015\u20102165"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/idh.12520"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jper.21\u20100351"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1972.43.1.38"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016357.2019.1703141"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1804727"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010021\u201001588\u2010y"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12109"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3290\/j.qi.a30606"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/idh.12539"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010020\u201001363\u20105"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13290"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58070866"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jper.20\u20100839"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9091966"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.19439\/j.sjos.2019.04.005"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.13029"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdsr.2022.09.001"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976\u20109668.198366"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12216936"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.12816\/0015178"}],"container-title":["International Journal of Dental Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/idh.12887","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T06:18:43Z","timestamp":1755843523000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/idh.12887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,17]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/idh.12887"],"URL":"https:\/\/doi.org\/10.1111\/idh.12887","archive":["Portico"],"relation":{},"ISSN":["1601-5029","1601-5037"],"issn-type":[{"type":"print","value":"1601-5029"},{"type":"electronic","value":"1601-5037"}],"subject":[],"published":{"date-parts":[[2024,12,17]]},"assertion":[{"value":"2024-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}