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Therefore, an umbrella review design was followed focused on review articles, that is, systematic and\/or narrative reviews of randomised clinical trials, observational or in\u00a0vitro studies whenever available. Seventy\u2010two reviews were identified through electronic search of OVID. Quality assessment was performed based upon the PRISMA checklist. Data was extracted according to relevance to the listed oral conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen toothpaste ingredients were identified to treat six oral conditions, including six types of fluoride. Evidence of efficacy of active ingredients varied and with six reported to have significant benefits for the prevention or treatment of the targeted oral condition. Differences were particularly evident in the efficacy of types of fluoride.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Toothpaste active ingredient efficacies are diverse. As such, oral healthcare providers should consider recommendation of toothpastes containing appropriate active ingredients by effectively targeting oral conditions\/diseases according to each patient's needs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/idh.12904","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T05:25:04Z","timestamp":1738214704000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Complex World of Toothpaste Diversity, Meeting Patient Clinical Needs. 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