{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:00:29Z","timestamp":1790362829221,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the effectiveness of cetylpyridinium chloride (CPC) and chlorhexidine (CHX) mouthwashes (MW) on plaque and gingivitis scores for patients with gingivitis, in brushing as well as non\u2010brushing situations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive search of MEDLINE\u2010PubMed and Cochrane\u2010CENTRAL was conducted to identify clinical and randomised controlled trials comparing CPC and CHX mouthwashes on plaque and gingivitis scores. The staining index was evaluated as a secondary outcome. In addition, the risk of bias was assessed. The data was summarised using a descriptive approach, and whenever possible, a meta\u2010analysis was conducted. The results for brushing and non\u2010brushing studies were presented separately. Grading was applied using the GRADE approach to rate the certainty of evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The search resulted in 424 unique papers, from which 14 full\u2010text papers providing 18 comparisons were selected. Different concentrations of CPC\u2010MW (0.1%, 0.075%, 0.05%) and CHX\u2010MW (0.2%, 0.12%) were used. The risk of bias was estimated to be low, moderate or high for each study. A meta\u2010analysis for non\u2010brushing models showed a significant favour for CHX\u2010MW in plaque index scores (0.55 [95% CI: 0.19; 0.91],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). For brushing, no significant differences were found between CPC\u2010MW and CHX\u2010MW. The descriptive analysis supports these findings. CHX\u2010MW tends to stain more than CPC\u2010MW.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is moderate certainty for a small statistically significant favourable effect of CHX\u2010MW over CPC\u2010MW for plaque control in non\u2010brushing situations, but no difference between them for plaque and gingivitis prevention in brushing situations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/idh.12916","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T05:59:44Z","timestamp":1750226384000},"page":"665-681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Effect of Cetylpyridinium Chloride Compared to Chlorhexidine Mouthwash on Scores of Plaque and Gingivitis: A Systematic Review and Meta\u2010Analyses"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1137-0136","authenticated-orcid":false,"given":"Emmy Rowan","family":"Windhorst","sequence":"first","affiliation":[{"name":"Department of Periodontology Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0180-6495","authenticated-orcid":false,"given":"Maud","family":"Joosstens","sequence":"additional","affiliation":[{"name":"Department of Periodontology Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1269-1710","authenticated-orcid":false,"given":"Eveline","family":"van der Sluijs","sequence":"additional","affiliation":[{"name":"Department of Periodontology Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7234-0037","authenticated-orcid":false,"given":"Dagmar Else","family":"Slot","sequence":"additional","affiliation":[{"name":"Department of Periodontology Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam  Amsterdam the 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