{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:00:36Z","timestamp":1790697636675,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004488","name":"Hrvatska Zaklada za Znanost","doi-asserted-by":"publisher","award":["IP\u20102020\u201002\u20104027"],"award-info":[{"award-number":["IP\u20102020\u201002\u20104027"]}],"id":[{"id":"10.13039\/501100004488","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate whether tobacco smoking modifies the clinical outcomes of non\u2010surgical periodontal therapy (NSPT) in adults with periodontitis and what are the added benefits of a chlorhexidine\u2010based antiseptic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sample included 60 subjects aged 24 to 75\u2009years (median 49; 67% females) diagnosed with periodontitis; 50% of them were regular smokers. All subjects underwent clinical periodontal examination that included measuring Full Mouth Plaque Score (FMPS), Full Mouth Bleeding Score (FMBS), Pocket Depth (PD), Clinical Attachment Level (CAL), Gingival Recession (GR) and Tooth Mobility (TM). All subjects underwent NSPT. Half of the subjects in each group used a 0.12% CHX\u2010based mouth\u2010rinse twice a day for 15\u2009days. Clinical examination was repeated 8\u2009weeks after NSPT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      FMPS significantly decreased after NSPT in all groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.013). FMBS was reduced in non\u2010smokers (with and without CHX) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.038) with a greater effect when using CHX. No major differences in FMBS in smokers were noted. NSPT reduced PD in all non\u2010smokers (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.016) with a greater effect with CHX use; and in smokers with CHX (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.016). The same findings were in gain of CAL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.028). The effect of NSPT on GR and TM was small. In multiple regression analysis, the use of CHX and male sex were significant predictors of a reduction in the proportion of deep pockets (\u2265\u20095\u2009mm), when age and exposure to tobacco smoke were controlled for (R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.170;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Smoking reduces the success of NSPT but the addition of antiseptic proved to be an additional benefit.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/idh.70059","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T03:10:59Z","timestamp":1776222659000},"page":"633-641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Does Exposure to Tobacco Smoke Modify the Clinical Periodontal Parameters After Non\u2010Surgical Periodontal Therapy With and Without the Addition of a Chlorhexidine\u2010Based Antiseptic? \u2010 A Controlled Clinical Trial"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9478-2060","authenticated-orcid":false,"given":"Aleksandar","family":"Pupovac","sequence":"first","affiliation":[{"name":"Department of Periodontology, Faculty of Dental Medicine University of Rijeka  Rijeka Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davor","family":"Kui\u0161","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dental Medicine University of Rijeka  Rijeka Croatia"},{"name":"Department of Periodontology Clinic of Dental Medicine, Clinical Hospital Center Rijeka  Rijeka Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Mi\u0161kovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Periodontology Clinic of Dental Medicine, Clinical Hospital Center Rijeka  Rijeka Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4836-3903","authenticated-orcid":false,"given":"Stjepan","family":"\u0160palj","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Dental Medicine University of Rijeka  Rijeka Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Sever","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Clinic of Dental Medicine, Clinical Hospital Center Rijeka  Rijeka Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Prpi\u0107","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dental Medicine University of Rijeka  Rijeka Croatia"},{"name":"Department of Periodontology Clinic of Dental Medicine, Clinical Hospital Center Rijeka  Rijeka Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2007.00212.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20075368"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13384"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2004.03793.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12106"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01371.x"},{"key":"e_1_2_12_8_1","first-page":"177","article-title":"A Review on Chlorhexidine in Periodontal Therapy","volume":"24","author":"Mahendra J.","year":"2020","journal-title":"Annals of the Romanian Society for Cell Biology"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2041-1626.2010.00031.x"},{"issue":"7","key":"e_1_2_12_10_1","first-page":"555","article-title":"Effect of Smoking on the Results of a Chlorhexidine Digluconate Treatment Extended up to 3 Months After Scaling and Root Planing\u2010A Pilot Study","volume":"42","author":"Stratul S. 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