{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:00:32Z","timestamp":1790697632102,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Nowadays, there is a trend to promote the use of natural materials in dentistry. One of these compounds that has lately grown significantly in relevance in clinical research is\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Pelargonium Graveolens<\/jats:italic>\n                      <\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      This study was conducted to evaluate the antimicrobial efficacy of gold nanoparticles (AuNPs) of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Pelargonium Graveolens<\/jats:italic>\n                      <\/jats:styled-content>\n                      leaves extract for children in comparison with the commonly used chlorhexidine. There are no previously available studies concerning the anti\u2010microbial activity of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Pelargonium Graveolens<\/jats:italic>\n                      <\/jats:styled-content>\n                      leaves.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Method<\/jats:title>\n                    <jats:p>\n                      Sixty participants with mild to moderate gingivitis were randomly allocated in a ratio of 1:1 to receive twice\u2010daily mouthwash for 3\u2009weeks (30 with a novel herbal mouthwash containing\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Pelargonium Graveolens<\/jats:italic>\n                      <\/jats:styled-content>\n                      AuNPs as a study group and 30 children with chlorhexidine as a control group). Clinical parameters (plaque index and gingival index) were assessed at the baseline (before the use of mouthwash), and then they were assessed 3 times at one\u2010week intervals after the first assessment through the period of the study. On the other hand, microbiological examination was done using supragingival plaque sampling with a curette for those participants at the baseline and three weeks after the use of the mouthwash.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After completing the intervention, although the study group had lower plaque scores compared to the control group, the difference was statistically significant. On the other hand, the study group had a significant reduction in the gingival index scores compared to the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.000). The microbiological analysis revealed that the treatment mouthwash significantly depleted the count of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>S. mutans<\/jats:italic>\n                      <\/jats:styled-content>\n                      in the last visit.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The novel\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Pelargonium Graveolens<\/jats:italic>\n                      <\/jats:styled-content>\n                      AuNPs mouthwash was effective in improving (PI) and (GI), which mean improve oral health status. Rinsing with\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Pelargonium Graveolens<\/jats:italic>\n                      <\/jats:styled-content>\n                      AuNPs mouthwash reduced the count of oral\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Streptococcus mutans<\/jats:italic>\n                      <\/jats:styled-content>\n                      significantly in children. Clinical trial registration Number:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      on April 15, 2023, with\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      ID: NCT05816512.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/idh.70071","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T03:45:54Z","timestamp":1777261554000},"page":"495-505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antimicrobial Efficacy of Pelargonium Graveolens Gold Nanoparticles: A Novel Mouthwash for Children"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8038-3475","authenticated-orcid":false,"given":"Ahmed Yousif Mahdi","family":"Asker","sequence":"first","affiliation":[{"name":"Department of Paediatric Dentistry, College of Dentistry University of Baghdad  Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4936-4927","authenticated-orcid":false,"given":"Aseel Haidar M. 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