{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:01:20Z","timestamp":1790830880462,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dental Hygiene"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Nitrous oxide\u2013oxygen (N\n 2<\/jats:sub>\n O\u2013O\n 2<\/jats:sub>\n ) inhalation is widely utilized for anxiolysis in dentistry; however, its clinical efficacy and physiological impact during routine supragingival scaling remain insufficiently assessed.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This prospective observational cohort study enrolled 100 adult patients. Participants were allocated to either the N\n 2<\/jats:sub>\n O\u2013O\n 2<\/jats:sub>\n sedation group (\n n<\/jats:italic>\n \u2009=\u200950) or a non\u2010sedated control group (\n n<\/jats:italic>\n \u2009=\u200950) based on treatment preference. Vital signs, including heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP), were monitored at baseline (T\n 0<\/jats:sub>\n ), intraoperatively (T\n 1<\/jats:sub>\n ), and postoperatively (T\n 2<\/jats:sub>\n ). Pain intensity was assessed immediately after supragingival ultrasonic scaling using a 0\u201310 Visual Analogue Scale.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n All 100 participants successfully completed the study. Intra\u2010group analysis revealed that the sedation group experienced a significant reduction in HR during scaling (T\n 1<\/jats:sub>\n ) compared to baseline (T\n 0<\/jats:sub>\n ,\n p<\/jats:italic>\n \u2009=\u20090.0004), whereas the control group remained physiologically stable with no significant HR fluctuations (\n p<\/jats:italic>\n \u2009>\u20090.05). SBP and DBP showed no significant intra\u2010group or inter\u2010group variations across all time points (\n p<\/jats:italic>\n \u2009>\u20090.05). Pain intensity was significantly lower in the sedation group compared with the control group (\n p<\/jats:italic>\n \u2009<\u20090.001). No adverse events were recorded.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n N\n 2<\/jats:sub>\n O\u2013O\n 2<\/jats:sub>\n inhalation sedation significantly attenuates procedural pain and stabilizes heart rate during supragingival ultrasonic scaling without compromising hemodynamic safety. These findings suggest N\n 2<\/jats:sub>\n O\u2013O\n 2<\/jats:sub>\n sedation is a safe and feasible adjunct for routine periodontal prophylaxis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/idh.70170","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:52:43Z","timestamp":1790830363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Nitrous Oxide\u2013Oxygen Inhalation on Pain and Physiological Responses During Supragingival Ultrasonic Scaling: A Prospective Cohort Study"],"prefix":"10.1111","author":[{"given":"Rong","family":"Tang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology Wuhan University Wuhan China"},{"name":"Dental Hygiene Centre, School & Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Yin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology Wuhan University Wuhan China"},{"name":"Department of Oral & Maxillofacial Surgery, School & Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Deng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology Wuhan University Wuhan China"},{"name":"Dental Hygiene Centre, School & Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology Wuhan University Wuhan China"},{"name":"Centre for Cariology, Endodontics and Periodontics, School & Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology Wuhan University Wuhan China"},{"name":"Comfort Dental Care Centre, School & Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3511-0697","authenticated-orcid":false,"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology Wuhan University Wuhan China"},{"name":"Department of Nursing, School & Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/prd.12361","article-title":"The dental plaque biofilm matrix","volume":"86","author":"Jakubovics N. 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