{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T20:45:32Z","timestamp":1773434732124,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":2495,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1111\/idj.12060","type":"journal-article","created":{"date-parts":[[2013,10,14]],"date-time":"2013-10-14T07:48:39Z","timestamp":1381736919000},"page":"34-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Efficacy and safety of bupivacaine versus lidocaine in dental treatments: a meta-analysis of randomised controlled trials"],"prefix":"10.1016","volume":"64","author":[{"given":"Naichuan","family":"Su","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1111\/idj.12060_bib1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0266-4356(02)00184-5","article-title":"Safety and efficacy of levobupivacaine for postoperative pain relief after the surgical removal of impacted third molar: a comparison with lidocaine and adrenaline","volume":"40","author":"Rood","year":"2002","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1111\/idj.12060_bib2","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0099-2399(98)80028-9","article-title":"Dental anxiety among patients undergoing endodontic treatment","volume":"24","author":"Peretz","year":"1998","journal-title":"J Endod"},{"key":"10.1111\/idj.12060_bib3","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/01.DON.0000125317.21892.8F","article-title":"Anesthetic efficacy of articaine for inferior alveolar nerve blocks in patient with irreversible pulpitis","volume":"30","author":"Claffey","year":"2004","journal-title":"J Endod"},{"key":"10.1111\/idj.12060_bib4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1034\/j.1600-0528.2002.300203.x","article-title":"Childhood dental fear in the Netherlands: prevalence and normative data","volume":"30","author":"ten Berge","year":"2002","journal-title":"Community Dent Oral Epidemiol"},{"key":"10.1111\/idj.12060_bib5","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.14219\/jada.archive.2009.0313","article-title":"The efficacy of six local anesthetic formulations used for posterior mandibular buccal infiltration anesthesia","volume":"140","author":"Abdulwahab","year":"2009","journal-title":"J Am Dent Assoc"},{"key":"10.1111\/idj.12060_bib6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1053\/bean.2003.0275","article-title":"Toxicity of local anesthetics","volume":"17","author":"Cox","year":"2003","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"10.1111\/idj.12060_bib7","series-title":"Handbook of Local Anesthesia","first-page":"52","article-title":"Clinical action of specific agents","author":"Malamed","year":"2012"},{"key":"10.1111\/idj.12060_bib8","doi-asserted-by":"crossref","first-page":"493","DOI":"10.14219\/jada.archive.2011.0219","article-title":"The pulpal anesthetic efficacy of articaine versus lidocaine in dentistry","volume":"142","author":"Brandt","year":"2011","journal-title":"J Am Dent Assoc"},{"key":"10.1111\/idj.12060_bib9","first-page":"649","article-title":"Survey of local anesthetic use by Ontario dentists","volume":"75","author":"Gaffen","year":"2009","journal-title":"J Can Dent Assoc"},{"key":"10.1111\/idj.12060_bib10","first-page":"92","article-title":"Dental therapeutic practice patterns in the U. S. I. anesthesia and sedation","volume":"54","author":"Moore","year":"2006","journal-title":"Gen Dent"},{"key":"10.1111\/idj.12060_bib11","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/0278-2391(84)90316-1","article-title":"Evaluation of etidocaine hydrochloride for local anesthesia and postoperative pain control in oral surgeries","volume":"42","author":"Sisk","year":"1984","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1111\/idj.12060_bib12","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.joen.2011.09.009","article-title":"Anesthetic efficacy of four percent articaine for pulpal anesthesia by using inferior alveolar nerve block and buccal infiltration techniques in patients with irreversible pulpitis: a prospective randomized double-blind clinical trial","volume":"37","author":"Poorni","year":"2011","journal-title":"J Endod"},{"key":"10.1111\/idj.12060_bib13","first-page":"53","article-title":"Long-acting local anesthetics in dentistry","volume":"39","author":"Sisk","year":"1992","journal-title":"Anesth Prog"},{"key":"10.1111\/idj.12060_bib14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/bja\/67.3.239","article-title":"Disposition of mepivacaine and bupivacaine enantiomers in sheep","volume":"67","author":"Mather","year":"1991","journal-title":"Br J Anaesth"},{"key":"10.1111\/idj.12060_bib15","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/bja\/80.3.289","article-title":"Extradural S(\u2013)-bupivacaine-comparison with racemic RS-bupivacaine","volume":"80","author":"Cox","year":"1998","journal-title":"Br J Anaesth"},{"key":"10.1111\/idj.12060_bib16","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1046\/j.1365-2125.1998.00775.x","article-title":"A comparison of the cardiovascular effects of levobupivacaine and rac-bupivacaine following intravenous administration to healthy volunteers","volume":"46","author":"Bardsley","year":"1998","journal-title":"Br J Clin Pharmacol"},{"key":"10.1111\/idj.12060_bib17","series-title":"Cochrane Handbook for Systematic Reviews of Interventions. 5.1.0 Version","first-page":"182","article-title":"Assessing risk of bias in included studies","author":"Higgins","year":"2011"},{"key":"10.1111\/idj.12060_bib18","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"key":"10.1111\/idj.12060_bib19","series-title":"Cochrane Handbook for Systematic Reviews of Interventions. 5.1.0 Version","first-page":"279","article-title":"Addressing reporting biases","author":"Sterne","year":"2011"},{"key":"10.1111\/idj.12060_bib20","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"Begg","year":"1994","journal-title":"Biometrics"},{"key":"10.1111\/idj.12060_bib21","series-title":"Cochrane Handbook for Systematic Reviews of Interventions. 5.1.0 Version","first-page":"429","article-title":"Special topics in statistics","author":"Higgins","year":"2011"},{"key":"10.1111\/idj.12060_bib22","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1016\/j.tripleo.2006.02.024","article-title":"Postoperative analgesia after lower third molar surgery: contribution of the use of long-acting local anesthetics, low-power laser, and diclofenac","volume":"102","author":"Markovic","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1111\/idj.12060_bib23","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1902\/jop.1986.57.10.637","article-title":"A comparison of postoperative pain experience pain following periodontal surgery using two local anesthetic agents","volume":"57","author":"Linden","year":"1986","journal-title":"J Periodontol"},{"key":"10.1111\/idj.12060_bib24","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1097\/01.don.0000167395.61075.38","article-title":"A prospective, randomized, double-blind comparison of bupivacaine and lidocaine for inferior alveolar nerve blocks","volume":"31","author":"Fernandez","year":"2005","journal-title":"J Endod"},{"key":"10.1111\/idj.12060_bib25","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.joen.2007.06.003","article-title":"A prospective, randomized, double-blind comparison of bupivacaine and lidocaine for maxillary infiltration","volume":"33","author":"Gross","year":"2007","journal-title":"J Endod"},{"key":"10.1111\/idj.12060_bib26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0030-4220(93)90136-R","article-title":"Analysis of the analgesic efficacy and cost-effective use of long-acting local anesthetics in outpatient third molar surgery","volume":"75","author":"Neal","year":"1993","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1111\/idj.12060_bib27","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/0030-4220(83)90175-5","article-title":"Bupivacaine anesthesia \u2013 a clinical trial for endodontic therapy","volume":"55","author":"Moore","year":"1983","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1111\/idj.12060_bib28","first-page":"113","article-title":"Clinical research of bupivacaine in endodontic treatment","volume":"7","author":"Xu","year":"1991","journal-title":"J Comprehensive Stomatol"},{"key":"10.1111\/idj.12060_bib29","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.joen.2012.01.008","article-title":"Comparison of the anesthetic efficacy between bupivacaine and lidocaine in patients with irreversible pulpits of mandibular molar","volume":"38","author":"Sampaio","year":"2012","journal-title":"J Endod"},{"key":"10.1111\/idj.12060_bib30","first-page":"5","article-title":"Comparison of postoperative bupivacaine with lidocaine on pain and analgesic use of following periodontal surgery","volume":"45","author":"Kaurich","year":"1997","journal-title":"J West Soc Periodontol Periodontal Abstr"},{"key":"10.1111\/idj.12060_bib31","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0300-9785(86)80131-4","article-title":"Long-acting local anesthetics in oral surgery: clinical evaluation of bupivacaine and etidocaine for mandibular nerve block","volume":"15","author":"Danielsson","year":"1986","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1111\/idj.12060_bib32","first-page":"65","article-title":"Long-acting local anesthetics in oral surgery: an experimental evaluation of bupivacaine and etidocaine for oral infiltration anesthesia","volume":"32","author":"Danielsson","year":"1985","journal-title":"Anesth Prog"},{"key":"10.1111\/idj.12060_bib33","first-page":"475","article-title":"A comparison of bupivacaine to lidocaine with respect to duration in the maxilla and mandible","volume":"53","author":"Teplitsky","year":"1987","journal-title":"J Can Dent Assoc"},{"key":"10.1111\/idj.12060_bib34","first-page":"305","article-title":"Anesthetic efficacy of levobupivacaine for surgical removal of impacted mandibular third molar and postoperative pain control","volume":"22","author":"Zhou","year":"2011","journal-title":"Med J Chin Peoples Armed Police Forces"},{"key":"10.1111\/idj.12060_bib35","first-page":"630","article-title":"Anesthetic efficacy of levobupivacaine for teeth preparation of vital pulp","volume":"26","author":"Zhou","year":"2010","journal-title":"J Clin Stomatol"},{"key":"10.1111\/idj.12060_bib36","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0099-2399(87)80097-3","article-title":"An evaluation of an electric pulp tester as a measure of analgesia in human vital teeth","volume":"13","author":"Dreven","year":"1987","journal-title":"J Endod"},{"key":"10.1111\/idj.12060_bib37","first-page":"25","article-title":"A clinical evaluation of the electric pulp tester as an indicator of local anesthesia","volume":"21","author":"Gertosimo","year":"1996","journal-title":"Oper Dent"},{"key":"10.1111\/idj.12060_bib38","series-title":"Seltzer and Bender\u2019s Dental Pulp","first-page":"165","author":"Hargreaves","year":"2002"},{"key":"10.1111\/idj.12060_bib39","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0030-4220(84)90340-2","article-title":"Evaluation of a digital pulptester","volume":"58","author":"Cooley","year":"1984","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1111\/idj.12060_bib40","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1213\/00000539-195911000-00018","article-title":"Different physical\u2013chemical and neuropharmacological properties of local anesthetic agents","volume":"38","author":"Truant","year":"1959","journal-title":"Anesth Analg"},{"key":"10.1111\/idj.12060_bib41","first-page":"98","article-title":"Physiology and pharmacology of local anesthetic agents","volume":"28","author":"Covino","year":"1981","journal-title":"Anesth Prog"},{"key":"10.1111\/idj.12060_bib42","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0300-9785(84)80017-4","article-title":"Pain control after third molar surgery","volume":"13","author":"Seymour","year":"1984","journal-title":"Int J Oral Surg"},{"key":"10.1111\/idj.12060_bib43","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S1042-3699(20)30625-7","article-title":"Perioperative pain control","volume":"4","author":"Shapiro","year":"1992","journal-title":"Oral Maxillofac Surg Clin North Am"},{"key":"10.1111\/idj.12060_bib44","first-page":"148","article-title":"Bupivacaine and lidocaine compared for postoperative pain control","volume":"37","author":"Caruso","year":"1989","journal-title":"Gen Dent"},{"key":"10.1111\/idj.12060_bib45","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1213\/00000539-199804000-00026","article-title":"The effect of verapamil and nimodipine on bupivacaine-induced cardiotoxicity in rats: an in vivo and in vitro study","volume":"86","author":"Adsan","year":"1998","journal-title":"Anesth Analg"},{"key":"10.1111\/idj.12060_bib46","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1213\/00000539-199303000-00040","article-title":"Enhancement of bupivacaine cardiotoxicity with cardiac glycosides and beta-adrenergic blockers: a case report","volume":"76","author":"Roitman","year":"1993","journal-title":"Anesth Analg"}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fidj.12060","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653920323650?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653920323650?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T10:40:11Z","timestamp":1758105611000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020653920323650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0020653920323650"],"URL":"https:\/\/doi.org\/10.1111\/idj.12060","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of bupivacaine versus lidocaine in dental treatments: a meta-analysis of randomised controlled trials","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/idj.12060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 FDI World Dental Federation. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}