{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:37:40Z","timestamp":1790757460667,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T00:00:00Z","timestamp":1358726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the effect of medicaments used in endodontic regeneration on root fracture resistance and microhardness of radicular dentine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>The root canals of mandibular premolars (<jats:italic>n<\/jats:italic>\u00a0=\u00a0180) were instrumented and randomized into three treatment groups and an untreated control group. Each treatment group received either triple antibiotic paste (<jats:styled-content style=\"fixed-case\">TAP<\/jats:styled-content>), double antibiotic paste (<jats:styled-content style=\"fixed-case\">DAP<\/jats:styled-content>) or calcium hydroxide paste [Ca(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)<jats:sub>2<\/jats:sub>] intracanal medicament. Teeth were kept in saline for 1\u00a0week, 1\u00a0month or 3\u00a0months. After each time\u2010point, 15 teeth were randomly selected from each group and two root cylinders were obtained from each tooth. One cylinder was subjected to a fracture resistance test, and the other cylinder was used for a microhardness test. Two\u2010way <jats:sc>anova<\/jats:sc> and Tukey's pairwise comparisons were used for statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For the microhardness test, the two\u2010way interaction between group and time was significant (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The intracanal application of <jats:styled-content style=\"fixed-case\">TAP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DAP<\/jats:styled-content> caused significant and continuous decrease in root dentine microhardness after one (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and 3\u00a0months (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), respectively. The three\u2010month intracanal application of Ca(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)<jats:sub>2<\/jats:sub> significantly increased the microhardness of root dentine (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The time factor had a significant effect on fracture resistance (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The three intracanal medicaments caused significant decreases in fracture resistance ranging between 19% and 30% after 3\u2010month application compared to 1\u2010week application.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this laboratory study, the 3\u2010month application of triple antibiotic paste, double antibiotic paste or calcium hydroxide paste medicaments significantly reduced the root fracture resistance of extracted teeth compared to a 1\u2010week application.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12046","type":"journal-article","created":{"date-parts":[[2012,12,14]],"date-time":"2012-12-14T12:28:14Z","timestamp":1355488094000},"page":"688-695","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["The effect of medicaments used in endodontic regeneration on root fracture and microhardness of radicular dentine"],"prefix":"10.1111","volume":"46","author":[{"given":"G. H.","family":"Yassen","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry Division of Dental Biomaterials Indiana University School of Dentistry Indianapolis IN USA"},{"name":"Department of Pediatric Orthodontic and Preventive Dentistry Mosul University School of Dentistry Mosul Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. M.","family":"Vail","sequence":"additional","affiliation":[{"name":"Department of Endodontics Indiana University School of Dentistry Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. G.","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry Division of Dental Biomaterials Indiana University School of Dentistry Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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