{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:33:52Z","timestamp":1788172432139,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,4,6]],"date-time":"2013-04-06T00:00:00Z","timestamp":1365206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the effect of preoperative oral ibuprofen (<jats:styled-content style=\"fixed-case\">IBU<\/jats:styled-content>) on the success of inferior alveolar nerve blocks (<jats:styled-content style=\"fixed-case\">IANB<\/jats:styled-content>s) with mepivacaine containing 1\u00a0:\u00a0100\u00a0000 epinephrine for patients with symptomatic irreversible pulpitis (<jats:styled-content style=\"fixed-case\">SIP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>The present study was a double\u2010blind, randomized, placebo\u2010controlled clinical trial. The study included two study groups each consisting of 25 patients who exhibited symptomatic irreversible pulpitis of a mandibular posterior tooth. The patients presented prolonged moderate or severe pain (&gt;10\u00a0s) after cold testing and indicated their pain scores on a Heft\u2010Parker visual analogue scale. The patients received identically appearing capsules containing either 600\u00a0mg <jats:styled-content style=\"fixed-case\">IBU<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">IBU<\/jats:styled-content>g) or gelatin (placebo, <jats:styled-content style=\"fixed-case\">PLA<\/jats:styled-content>g) 1\u00a0h before administration of <jats:styled-content style=\"fixed-case\">IANB<\/jats:styled-content> with 2% mepivacaine containing 1\u00a0:\u00a0100\u00a0000 epinephrine. After 15\u00a0min, the anaesthetic blockade was assessed by a three\u2010step examination (lip numbness, positive\/negative response to cold testing and clinical discomfort during endodontic access). <jats:styled-content style=\"fixed-case\">IANB<\/jats:styled-content> success was defined as the absence of pain during any of these evaluations. The data were analysed using the chi\u2010squared test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All of the patients reported moderate or severe pain before the preoperative procedure. Statistically significant differences were observed between the <jats:styled-content style=\"fixed-case\">IBU<\/jats:styled-content>g and <jats:styled-content style=\"fixed-case\">PLA<\/jats:styled-content>g (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05); the success rates for the <jats:styled-content style=\"fixed-case\">IANB<\/jats:styled-content> were 72% (<jats:styled-content style=\"fixed-case\">IBU<\/jats:styled-content>g) and 36% (<jats:styled-content style=\"fixed-case\">PLA<\/jats:styled-content>g).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preoperative oral administration of <jats:styled-content style=\"fixed-case\">IBU<\/jats:styled-content> significantly improved the efficacy of <jats:styled-content style=\"fixed-case\">IANB<\/jats:styled-content> in patients with symptomatic irreversible pulpitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12099","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T02:16:39Z","timestamp":1363140999000},"page":"1056-1062","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Efficacy of preoperative ibuprofen on the success of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a randomized clinical trial"],"prefix":"10.1111","volume":"46","author":[{"given":"D.","family":"Noguera\u2010Gonzalez","sequence":"first","affiliation":[{"name":"Endodontic Postgraduate Program and Basic Sciences Laboratory Faculty of Dentistry Universidad Aut\u00f3noma de San Luis Potos\u00ed San Luis Potos\u00ed M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. I.","family":"Cerda\u2010Cristerna","sequence":"additional","affiliation":[{"name":"Endodontic Postgraduate Program and Basic Sciences Laboratory Faculty of Dentistry Universidad Aut\u00f3noma de San Luis Potos\u00ed San Luis Potos\u00ed M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Chavarria\u2010Bola\u00f1os","sequence":"additional","affiliation":[{"name":"Endodontic Postgraduate Program and Basic Sciences Laboratory Faculty of Dentistry Universidad Aut\u00f3noma de San Luis Potos\u00ed San Luis Potos\u00ed M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Flores\u2010Reyes","sequence":"additional","affiliation":[{"name":"Endodontic Postgraduate Program and Basic Sciences Laboratory Faculty of Dentistry Universidad Aut\u00f3noma de San Luis Potos\u00ed San Luis Potos\u00ed M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pozos\u2010Guillen","sequence":"additional","affiliation":[{"name":"Endodontic Postgraduate Program and Basic Sciences Laboratory Faculty of Dentistry Universidad Aut\u00f3noma de San Luis Potos\u00ed San Luis Potos\u00ed M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.11.010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-8-200104170-00012"},{"key":"e_1_2_7_4_1","first-page":"e39","article-title":"Anesthetic efficacy of articaine for inferior alveolar nerve blocks in patients with symptomatic versus asymptomatic irreversible pulpitis","volume":"60","author":"Argueta\u2010Figueroa L","year":"2012","journal-title":"General Dentistry"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.53.157"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.089771"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.211bf.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.5001\/omj.2010.49"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.DON.0000125317.21892.8F"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(06)81366-X"},{"key":"e_1_2_7_11_1","first-page":"139","volume-title":"Pharmacology of Pain","author":"Cummins TR","year":"2010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2011.01853.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.3.1108"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2004.04.005"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-1546.2002.10103.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2006.09.007"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.don.0000158239.97520.de"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2010.06.008"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2006.09.005"},{"key":"e_1_2_7_20_1","first-page":"209","article-title":"Preoperative oral nonsteroidal anti\u2010inflammatory drugs for the success of the inferior alveolar nerve block in irreversible pulpitis treatment: a systematic review and meta\u2010analysis based on randomized controlled trials","volume":"43","author":"Li C","year":"2012","journal-title":"Quintessence International"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2006.09.010"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.10.053"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(06)80438-3"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2009.12.003"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.12.030"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2010.05.007"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2010.01833.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-009-0016-x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.86.2.629"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-5-5"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-1546.2002.30108.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.79.4.1746"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.02.015"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411980090040701"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1986.85"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2007.05.023"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2702.2005.01121.x"}],"container-title":["International Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiej.12099","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiej.12099","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.12099","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iej.12099","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.12099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T22:23:26Z","timestamp":1693952606000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iej.12099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,6]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1111\/iej.12099"],"URL":"https:\/\/doi.org\/10.1111\/iej.12099","archive":["Portico"],"relation":{},"ISSN":["0143-2885","1365-2591"],"issn-type":[{"value":"0143-2885","type":"print"},{"value":"1365-2591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,6]]},"assertion":[{"value":"2012-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}