{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T02:55:29Z","timestamp":1775789729210,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T00:00:00Z","timestamp":1367971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the efficacy of a single buccal infitration using 4% articaine hydrochloride (<jats:styled-content style=\"fixed-case\">HCl<\/jats:styled-content>) with 1\u00a0:\u00a0100\u00a0000 epinephrine or 4% articaine <jats:styled-content style=\"fixed-case\">HCl<\/jats:styled-content> with 1\u00a0:\u00a0100\u00a0000 epinephrine bitartrate for obtaining adequate pulpal anaesthesia in the palatal roots of maxillary first molars associated with irreversible pulpitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>In this single\u2010blind randomized clinical trial, fifty subjects were randomly allocated to receive maxillary buccal injections of 1.5\u00a0mL 4% articaine with 1\u00a0:\u00a0100\u00a0000 epinephrine (<jats:italic>n<\/jats:italic>\u00a0=\u00a025) or 1.5\u00a0mL 4% articaine with 1\u00a0:\u00a0100\u00a0000 epinephrine bitartrate (<jats:italic>n<\/jats:italic>\u00a0=\u00a025). Visual analogue scale (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>) scores and pulse rate measurements were recorded during access cavity preparation and initial file placement into the mesiobuccal, distobuccal and palatal canals. Data were analysed using Duncan and <jats:italic>t<\/jats:italic>\u2010tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference between the two anaesthetic solutions regarding the <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> scores and pulse rate measurements during endodontic procedures. The mean <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> ratings of the 50 patients during file placement into the palatal canals were significantly higher compared with the other three root canal procedures (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001). The heart rates during negotiation of palatal canals were significantly higher than when negotiating the mesiobuccal and distobuccal canals (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Single buccal infiltration did not achieve adequate pulpal anaesthesia in the palatal root canal of the maxillary first molars associated with irreversible pulpitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12129","type":"journal-article","created":{"date-parts":[[2013,4,24]],"date-time":"2013-04-24T08:12:56Z","timestamp":1366791176000},"page":"222-227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Efficacy of single buccal infiltrations for maxillary first molars in patients with irreversible pulpitis: a randomized controlled clinical trial"],"prefix":"10.1111","volume":"47","author":[{"given":"\u00d6. \u0130.","family":"Atasoy Ulusoy","sequence":"first","affiliation":[{"name":"Department of Endodontics Faculty of Dentistry Gazi University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Ala\u00e7am","sequence":"additional","affiliation":[{"name":"Department of Endodontics Faculty of Dentistry Gazi University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.04.012"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.DON.0000125317.21892.8F"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.01.004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2008.08.025"},{"key":"e_1_2_6_6_1","first-page":"217","article-title":"Lack of differential effect by Ultracaine (articaine) and Citanest (prilocaine) in infiltration anesthesia","volume":"57","author":"Haas DA","year":"1991","journal-title":"Journal of the Canadian Dental Association"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(84)90835-2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1984.0470"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8177(88)72020-6"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2001.0152"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.11.025"},{"key":"e_1_2_6_12_1","first-page":"59","article-title":"Review of local anaesthetic agents","volume":"71","author":"McLure HA","year":"2005","journal-title":"Minerva Anestesiologica"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.12.023"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2012.0294"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-06489-7.00020-5"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.02.016"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2008.09.002"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.12.005"}],"container-title":["International Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiej.12129","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.12129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T17:31:37Z","timestamp":1696354297000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iej.12129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,8]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/iej.12129"],"URL":"https:\/\/doi.org\/10.1111\/iej.12129","archive":["Portico"],"relation":{},"ISSN":["0143-2885","1365-2591"],"issn-type":[{"value":"0143-2885","type":"print"},{"value":"1365-2591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,8]]},"assertion":[{"value":"2012-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}