{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:27:26Z","timestamp":1790123246395,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T00:00:00Z","timestamp":1372723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To develop and characterize a salicylate resin with potential use in bioactive endodontic sealers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Methyl salicylate, glycerol and titanium isopropoxide were added in a closed system for the transesterification reaction. The resin obtained was characterized by proton nuclear magnetic resonance spectroscopy (1H <jats:styled-content style=\"fixed-case\">NMR<\/jats:styled-content>) and size exclusion chromatography (<jats:styled-content style=\"fixed-case\">SEC<\/jats:styled-content>). To verify the applicability of the resin to the development of endodontic sealers, experimental cements were prepared by mixing glycerol salicylate resin, calcium hydroxide and methyl salicylate in the ratios of 2\u2009:\u20091\u2009:\u20091, 1\u2009:\u20092\u2009:\u20091, 1\u2009:\u20091\u2009:\u20092, 1\u2009:\u20091\u2009:\u20091, 4\u2009:\u20091\u2009:\u20091, 1\u2009:\u20094\u00a0:\u20091 and 1\u2009:\u20091\u2009:\u20094. Setting times were measured according to <jats:styled-content style=\"fixed-case\">ISO<\/jats:styled-content> 6876. Features of the hardening reaction were described by micro\u2010<jats:styled-content style=\"fixed-case\">RAMAN<\/jats:styled-content> spectroscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The transesterification reaction had a 72% efficiency. The <jats:sup>1<\/jats:sup>H <jats:styled-content style=\"fixed-case\">NMR<\/jats:styled-content> analysis revealed the presence of the expected functional groups (hydroxyls and aromatic rings), and the <jats:styled-content style=\"fixed-case\">SEC<\/jats:styled-content> confirmed the molar mass of the resin produced. The setting times of experimental sealers ranged from 70\u00a0min (ratio 1\u00a0:\u00a01\u00a0:\u00a01) to 490\u00a0min (ratio 1\u00a0:\u00a01\u00a0:\u00a04). The conversion of the salicylic groups (1 613\u00a0cm<jats:sup>\u22121<\/jats:sup>) to salicylate salt (1 543\u00a0cm<jats:sup>\u22121<\/jats:sup>) and the reduction in calcium hydroxide peaks (1084 and 682\u00a0cm<jats:sup>\u22121<\/jats:sup>) were confirmed by micro\u2010<jats:styled-content style=\"fixed-case\">RAMAN<\/jats:styled-content> spectroscopy, which showed the calcium chelation by the resin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The new glycerol salicylate resin was successfully synthesized and revealed a potential application in the development of endodontic sealers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12149","type":"journal-article","created":{"date-parts":[[2013,6,7]],"date-time":"2013-06-07T08:05:13Z","timestamp":1370592313000},"page":"339-345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Synthesis and characterization of a glycerol salicylate resin for bioactive root canal sealers"],"prefix":"10.1111","volume":"47","author":[{"given":"F. 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L.","family":"Petzhold","sequence":"additional","affiliation":[{"name":"Institute of Chemistry Federal University of Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. M.","family":"Collares","sequence":"additional","affiliation":[{"name":"Dental Materials Laboratory School of Dentistry Federal University of Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M. 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