{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:19:43Z","timestamp":1782296383332,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,7,29]],"date-time":"2013-07-29T00:00:00Z","timestamp":1375056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this randomized controlled, double\u2010blind trial was to comparatively evaluate the anaesthetic efficacy and injection pain of 1.8\u00a0mL of 2% lidocaine with different concentrations of epinephrine (1\u00a0:\u00a080\u00a0000 and 1\u00a0:\u00a0200\u00a0000) in patients with symptomatic irreversible pulpitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Sixty\u2010two adult volunteers, actively experiencing pain, were randomly allocated into 2 groups and received 1.8\u00a0mL of 2% lidocaine with either 1\u00a0:\u00a080\u00a0000 or 1\u00a0:\u00a0200\u00a0000 epinephrine concentration. Endodontic access preparation was initiated 15\u00a0min after the initial IANB. Pain during treatment was recorded using the Heft\u2010Parker visual analogue scale (HP VAS). The primary outcome measure, and the definition of \u2018success\u2019, was the ability to undertake pulp access and canal instrumentation with no or mild pain (HP VAS score &lt;55\u00a0mm). Secondary outcome measure was the pain experienced during LA solution deposition. Statistical analysis was performed using Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test and chi\u2010square test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The anaesthetic success rates of 2% lidocaine solutions containing 1\u00a0:\u00a080\u00a0000 and 1\u00a0:\u00a0200\u00a0000 epinephrine concentrations were 20% and 28%, respectively. The difference was not statistically significant. There was also no significant difference in the pain experienced during deposition of the solutions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Two percent lidocaine solution used for <jats:styled-content style=\"fixed-case\">IANB<\/jats:styled-content> achieved similar success rates when used with 1\u00a0:\u00a080\u00a0000 or 1\u00a0:\u00a0200\u00a0000 epinephrine concentration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12157","type":"journal-article","created":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T20:56:22Z","timestamp":1372884982000},"page":"373-379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Comparison of the anaesthetic efficacy of epinephrine concentrations (1\u00a0:\u00a080\u00a0000 and 1\u00a0:\u00a0200\u00a0000) in 2% lidocaine for inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a randomized, double\u2010blind clinical trial"],"prefix":"10.1111","volume":"47","author":[{"given":"V.","family":"Aggarwal","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry &amp; Endodontics Faculty of Dentistry Jamia Millia Islamia New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Singla","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry &amp; Endodontics SGT Dental College Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Miglani","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry &amp; Endodontics Faculty of Dentistry Jamia Millia Islamia New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kohli","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry &amp; Endodontics Faculty of Dentistry Jamia Millia Islamia New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,29]]},"reference":[{"key":"e_1_2_6_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(80)80051-2"},{"key":"e_1_2_6_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.04.012"},{"key":"e_1_2_6_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.01.016"},{"key":"e_1_2_6_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.02.003"},{"key":"e_1_2_6_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2007.07.019"},{"key":"e_1_2_6_3_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01221946"},{"key":"e_1_2_6_3_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.DON.0000125317.21892.8F"},{"key":"e_1_2_6_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(97)80271-3"},{"key":"e_1_2_6_3_10_1","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/0030-4220(92)90367-Y","article-title":"Contraindications to vasoconstrictors in dentistry, part III: pharmacologic interactions","volume":"74","author":"Goulet JP","year":"1992","journal-title":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics"},{"key":"e_1_2_6_3_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-1546.2002.10103.x"},{"key":"e_1_2_6_3_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200306000-00004"},{"key":"e_1_2_6_3_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308200514"},{"key":"e_1_2_6_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(84)90835-2"},{"key":"e_1_2_6_3_15_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2006.0092"},{"key":"e_1_2_6_3_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2001.01357.x"},{"key":"e_1_2_6_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.12.006"},{"key":"e_1_2_6_3_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200310000-00004"},{"key":"e_1_2_6_3_19_1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0030-4220(92)90091-4","article-title":"Pulpal anesthesia dependent on epinephrine dose in 2% lidocaine. 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