{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:26:40Z","timestamp":1784647600943,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This randomized double\u2010blinded controlled trial was performed to compare the efficacy of inferior alveolar nerve block (<jats:styled-content style=\"fixed-case\">IANB<\/jats:styled-content>) injection for mandibular first molar teeth with irreversible pulpitis with or without supplementary buccal infiltration and intraligamentary injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Eighty\u2010two patients with asymptomatic irreversible pulpitis received either a combination of intraligamentary injection\u00a0+\u00a0buccal infiltration+\u00a0<jats:styled-content style=\"fixed-case\">IANB<\/jats:styled-content> or with traditional <jats:styled-content style=\"fixed-case\">IANB<\/jats:styled-content> injection in mandibular first molar teeth with irreversible pulpitis. Each patient recorded their pain score on a Heft\u2013Parker visual analogue scale before commencing treatment, in response to a cold test 15\u00a0min after the designated anaesthetic injection, during access cavity preparation and during root canal instrumentation. No or mild pain at any stage was considered a success. Data were analysed by chi\u2010square test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the final stage of treatment, 69 of the 82 patients were eligible to be included in the study. No significant difference was found between age (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.569) and gender (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.570) amongst the patients in the two groups. The success rate of anaesthesia in the <jats:styled-content style=\"fixed-case\">IANB<\/jats:styled-content> and the combination groups were 22% and 58%, respectively. The success rate of anaesthesia in the combination group was significantly higher than the traditional <jats:styled-content style=\"fixed-case\">IANB<\/jats:styled-content> injection (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A combination of anaesthetic techniques can improve the success rate of anaesthesia for mandibular first molar teeth with irreversible pulpitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12236","type":"journal-article","created":{"date-parts":[[2013,12,21]],"date-time":"2013-12-21T07:46:57Z","timestamp":1387612017000},"page":"926-933","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Efficacy of supplementary buccal infiltrations and intraligamentary injections to inferior alveolar nerve blocks in mandibular first molars with asymptomatic irreversible pulpitis: a randomized controlled trial"],"prefix":"10.1111","volume":"47","author":[{"given":"M.","family":"Parirokh","sequence":"first","affiliation":[{"name":"Oral and Dental Diseases Research Center Kerman University of Medical Sciences Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sadr","sequence":"additional","affiliation":[{"name":"Persian Gulf Oral and Dental Diseases Research Center Endodontic Department, Faculty of Dentistry Hormozgan University of Medical Sciences, Bandar Abbas Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Nakhaee","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center Kerman University of Medical Sciences Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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