{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T08:43:28Z","timestamp":1781685808204,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T00:00:00Z","timestamp":1394582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Allergy to materials used during root canal treatment is well recognized in the endodontic literature. However, allergy to Ledermix paste, a compound containing triamcinolone (a corticosteroid) and demeclocycline (a tetracycline antibiotic), has not been reported apart from one very recent case in a Letter to the Editor of a journal. The aim of this report is to describe a proven allergic reaction to tetracycline following the use of Ledermix paste as a root canal medicament.<\/jats:p><\/jats:sec><jats:sec><jats:title>Summary<\/jats:title><jats:p>A 33\u2010year\u2010old female patient undergoing root canal retreatment of her right mandibular second premolar tooth experienced symptoms of type 1 allergy following the placement of an intracanal medicament containing a mixture of Ledermix paste and calcium hydroxide [Ca(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)<jats:sub>2<\/jats:sub>]. Signs of the type 1 allergy included urticaria, pruritus all over the body, general malaise and fever. These all subsided after removing and flushing out the Ledermix paste\u2013Ca(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)<jats:sub>2<\/jats:sub> mixture and redressing the root canal with Ca(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)<jats:sub>2<\/jats:sub> alone. Allergic scratch tests were performed, and these confirmed that the patient was allergic to tetracycline, one of the components of Ledermix paste.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12252","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T17:32:13Z","timestamp":1390498333000},"page":"1090-1097","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Allergic reaction to the tetracycline component of Ledermix paste: a case report"],"prefix":"10.1111","volume":"47","author":[{"given":"A. 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