{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:09:46Z","timestamp":1788527386882,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T00:00:00Z","timestamp":1396396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To record the incidence of lesions that were not the sequelae of pulpal necrosis (non\u2010<jats:styled-content style=\"fixed-case\">SPN<\/jats:styled-content>) amongst 1521 biopsies of periapical lesions submitted with a clinical diagnosis of a sequelae of pulpal necrosis (<jats:styled-content style=\"fixed-case\">SPN<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>A retrospective study of 1521 biopsy request forms of specimens submitted for histopathological examination with a clinical diagnosis \u2018periapical inflammation\u2019, \u2018periapical abscess\u2019, \u2018periapical granuloma\u2019 or \u2018periapical cyst\u2019 during an arbitrarily selected 14\u2010year period was undertaken. Gender and age of the patient, site and maximum diameter of the lesion, symptoms, inclusion of the final diagnosis in the differential diagnosis and specialty of the clinician submitting the biopsy material were recorded in each case. The final diagnosis for each case was extracted from the pathology report, and two groups were formed, <jats:styled-content style=\"fixed-case\">SPN<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">SPN<\/jats:styled-content> lesions. Differences between the respective features of <jats:styled-content style=\"fixed-case\">SPN<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">SPN<\/jats:styled-content> cases were analysed with Yate's chi\u2010square test and <jats:italic>t<\/jats:italic>\u2010test (significance level <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05)<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 52 of the 1521 cases examined (3.42%), the histological diagnosis was not consistent with a <jats:styled-content style=\"fixed-case\">SPN<\/jats:styled-content>. In most non\u2010<jats:styled-content style=\"fixed-case\">SPN<\/jats:styled-content> cases, the histopathological diagnosis was not included in the differential diagnosis. The keratocystic odontogenic tumour [odontogenic keratocyst (<jats:styled-content style=\"fixed-case\">OKC<\/jats:styled-content>)] was the most frequent non\u2010<jats:styled-content style=\"fixed-case\">SPN<\/jats:styled-content> lesion (34.62%). Other, yet less frequent, non\u2010<jats:styled-content style=\"fixed-case\">SPN<\/jats:styled-content> lesions included glandular odontogenic cysts, lateral periodontal cysts, central ossifying fibromas as well as malignancies (metastatic carcinomas and Langerhans cell histiocytosis).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Non\u2010<jats:styled-content style=\"fixed-case\">SPN<\/jats:styled-content> lesions appeared in the periapical region mimicking a <jats:styled-content style=\"fixed-case\">SPN<\/jats:styled-content>, although rarely. Most of them were developmental cysts, in particular <jats:styled-content style=\"fixed-case\">OKC<\/jats:styled-content>s, but odontogenic tumours, such as ameloblastoma, or malignant lesions were also diagnosed. Histological examination of tissue harvested from periapical lesions should be performed, in particular when those lesions are large.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12276","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T09:36:11Z","timestamp":1393839371000},"page":"68-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Periapical lesions are not always a sequelae of pulpal necrosis: a retrospective study of 1521 biopsies"],"prefix":"10.1111","volume":"48","author":[{"given":"T. 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