{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:14:27Z","timestamp":1790486067861,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,4,5]],"date-time":"2014-04-05T00:00:00Z","timestamp":1396656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Natural Science Fund of Guangdong province, China","award":["Grant S2012010010393"],"award-info":[{"award-number":["Grant S2012010010393"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the effect of chronic periodontitis on dental pulps by assessing histological changes in the pulps of teeth with moderate\u2010to\u2010severe periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>A total of 242 teeth from 162 patients with moderate\u2010to\u2010severe periodontitis were collected, and histological changes in pulps were investigated by staining with haematoxylin and eosin. Baseline data were taken from the patients' records before extraction. The morphologic changes observed in the pulp were classified as degree I, degree II, degree III and degree IV. Statistical analysis of the severity of periodontitis and histological changes with the pulps was applied using the Mann\u2013Whitney <jats:italic>U<\/jats:italic> rank sum test, whilst the contingency coefficient was used to analyse the inter\u2010relationship between the severity of periodontitis and histological changes in the pulps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The inter\u2010relationship between the severity of periodontitis and histological changes in the pulps was 0.274 (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001), and significant differences existed between teeth with moderate periodontitis and severe periodontitis group (<jats:italic>Z<\/jats:italic>\u00a0=\u00a04.145, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). The inter\u2010relationship between attachment loss and histological changes in the pulps was 0.397 (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). There were significant differences in the histological changes amongst teeth with various degrees of attachment loss (\u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a033.023, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001) and amongst teeth in different locations (\u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a023.163, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was a positive association between the severity of periodontitis and histological changes within the pulp. More attachment loss was correlated with pathological changes within the dental pulp.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12282","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T06:59:41Z","timestamp":1395298781000},"page":"95-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Histological changes within dental pulps in teeth with moderate\u2010to\u2010severe chronic periodontitis"],"prefix":"10.1111","volume":"48","author":[{"given":"L.","family":"Wan","sequence":"first","affiliation":[{"name":"Guangdong Provincial Stomatological Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. B.","family":"Lu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Stomatological Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Y.","family":"Xuan","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Stomatological Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. X.","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics School of Public Health and Tropical Medicine Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Stomatological Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1978.tb01907.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1984.55.2.63"},{"key":"e_1_2_7_4_1","first-page":"725","article-title":"Microscopic aspects of pulpal changes in patients with chronic marginal periodontitis","volume":"53","author":"Caraivan O","year":"2012","journal-title":"Romanian Journal of Morphology and Embryology"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(79)80018-7"},{"key":"e_1_2_7_6_1","first-page":"699","article-title":"Scanning electron microscopic investigation of incidence, location, and size of accessory foramina in primary and permanent molars","volume":"35","author":"Dammaschke T","year":"2004","journal-title":"Quintessence International"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1978.49.1.21"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.03012.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1980.51.4.217"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1995.tb00309.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(74)90421-6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(64)90363-9"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.84"},{"key":"e_1_2_7_14_1","first-page":"18","article-title":"The 14 warning signs","volume":"4","author":"Petka K","year":"2001","journal-title":"Endodontic Practice"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0906-6713.2003.003431.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1965.36.1.34"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(63)90385-2"},{"key":"e_1_2_7_18_1","first-page":"593","article-title":"The periodontal endodontic controversies: a review","volume":"12","author":"Shukla P","year":"2010","journal-title":"Journal of the Indian Dental Association"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1964.35.1.22"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(72)90424-0"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(77)90250-X"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(85)90018-0"},{"key":"e_1_2_7_23_1","first-page":"651","volume-title":"Pathways of the Pulp","author":"Wang HL","year":"2002"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1989.tb00359.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.060112"},{"key":"e_1_2_7_26_1","first-page":"271350","article-title":"Histopathological features of dental pulp in teeth with different levels of chronic periodontitis severity","volume":"2012","author":"Zuza EP","year":"2012","journal-title":"ISRN Dentisrty"}],"container-title":["International Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiej.12282","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.12282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T01:24:56Z","timestamp":1696296296000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iej.12282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,5]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/iej.12282"],"URL":"https:\/\/doi.org\/10.1111\/iej.12282","archive":["Portico"],"relation":{},"ISSN":["0143-2885","1365-2591"],"issn-type":[{"value":"0143-2885","type":"print"},{"value":"1365-2591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,5]]},"assertion":[{"value":"2013-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-04-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}