{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T20:37:29Z","timestamp":1773088649077,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T00:00:00Z","timestamp":1397779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the anaesthetic efficacy of different volumes (1.8\u00a0mL vs. 3.6\u00a0mL) of 4% articaine with 1\u00a0:\u00a0100\u00a0000 epinephrine injected as buccal infiltrations after a failed inferior alveolar nerve block (IANB) in patients with symptomatic irreversible pulpitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Two hundred and thirty\u2010four adult patients, diagnosed with irreversible pulpitis in a mandibular tooth, participated in this multicentre, randomized double\u2010blinded trial. Patients received IANB with 1.8\u00a0mL of 4% articaine with 1\u00a0:\u00a0100\u00a0000 epinephrine. Pain during treatment was recorded using the Heft\u2013Parker visual analogue scale (HP VAS). The primary outcome measure, and the definition of \u2018success\u2019, was the ability to undertake pulp chamber access and canal instrumentation with no or mild pain (HP VAS score &lt;55\u00a0mm). Patients who experienced \u2018moderate\u2010to\u2010severe\u2019 pain (HP VAS score \u226555\u00a0mm) were randomly allocated into two groups and received buccal infiltrations with either 1.8\u00a0mL or 3.6\u00a0mL of 4% articaine with 1\u00a0:\u00a0100\u00a0000 epinephrine. Root canal treatment was re\u2010initiated after 10\u00a0min. Success was again defined as no pain or weak\/mild pain during endodontic access preparation and instrumentation. Statistical analysis was performed using Mann\u2013Whitney <jats:italic>U<\/jats:italic> and chi\u2010square tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The initial IANB of 4% articaine gave an overall success rate of 37%. The success rate of supplementary buccal infiltration with 1.8 and 3.6\u00a0mL volumes was 62% and 64%, respectively. The difference between the success rates of the two volumes was not statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increasing the volume of 4% articaine with 1\u00a0:\u00a0100\u00a0000 epinephrine from 1.8 to 3.6\u00a0mL, given as supplementary buccal infiltrations after a failed primary IANB with 1.8\u00a0mL of 4% articaine with 1\u00a0:\u00a0100\u00a0000, did not improve the anaesthetic success rates in patients with symptomatic irreversible pulpitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12283","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T03:11:18Z","timestamp":1395717078000},"page":"103-108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Comparison of the anaesthetic efficacy of different volumes of 4% articaine (1.8 and 3.6\u00a0mL) as supplemental buccal infiltration after failed inferior alveolar nerve block"],"prefix":"10.1111","volume":"48","author":[{"given":"M.","family":"Singla","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry &amp; Endodontics SGT Dental College Gurgaon India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Subbiya","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry &amp; Endodontics Sree Balaji Dental College and Hospital Bharath University Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry &amp; Endodontics Faculty of Dentistry Jamia Millia Islamia New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Vivekanandhan","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry &amp; Endodontics Sree Balaji Dental College and Hospital Bharath University Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry &amp; 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