{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:57:50Z","timestamp":1790117870395,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T00:00:00Z","timestamp":1400025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Sciences","award":["22592118"],"award-info":[{"award-number":["22592118"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate two fast\u2010setting calcium silicate\u2010based endodontic materials (Endocem mineral trioxide aggregate <jats:styled-content style=\"fixed-case\">(MTA)<\/jats:styled-content> and Endocem Zr) with regard to their ability to release calcium ions (Ca<jats:sup>2+<\/jats:sup>) and produce apatite\u2010like precipitates after immersion in phosphate\u2010buffered saline (<jats:styled-content style=\"fixed-case\">PBS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Endocem <jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content>, Endocem Zr and white ProRoot <jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">WMTA<\/jats:styled-content>) were used. Chemical composition of the powder of each material was analysed with a wavelength\u2010dispersive X\u2010ray spectroscopy electron probe microanalyser with image observation function (<jats:styled-content style=\"fixed-case\">SEM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EPMA<\/jats:styled-content>). The amount of Ca<jats:sup>2+<\/jats:sup> released from water\u2010immersed set cements was measured with an <jats:styled-content style=\"fixed-case\">EDTA<\/jats:styled-content> titration method. Morphology and chemical composition of surface precipitates formed on the surface of <jats:styled-content style=\"fixed-case\">PBS<\/jats:styled-content>\u2010immersed cements were analysed with the <jats:styled-content style=\"fixed-case\">SEM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EPMA<\/jats:styled-content>. Data obtained were analysed using one\u2010way analysis of variance and Tukey's honestly significant difference test with a significance level of 5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Endocem <jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">WMTA<\/jats:styled-content> contained calcium (Ca), silicon (Si) and bismuth as the major elemental constituents, whereas Endocem Zr contained zirconium as the most abundant element, followed by Ca and Si. The amount of Ca<jats:sup>2+<\/jats:sup> release was <jats:styled-content style=\"fixed-case\">WMTA<\/jats:styled-content> &gt;Endocem <jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content> \u2265Endocem Zr. After immersion in <jats:styled-content style=\"fixed-case\">PBS<\/jats:styled-content> for 14\u00a0days, the three materials produced Ca\u2010 and phosphorus (P)\u2010containing apatite\u2010like surface precipitates. <jats:styled-content style=\"fixed-case\">WMTA<\/jats:styled-content> showed higher Ca\/P ratio of the precipitates compared with the other cements, with statistical significance between <jats:styled-content style=\"fixed-case\">WMTA<\/jats:styled-content> and Endocem Zr (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared with <jats:styled-content style=\"fixed-case\">WMTA<\/jats:styled-content>, Endocem <jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content> and Endocem Zr were associated with significantly less Ca ions release and, when immersed in <jats:styled-content style=\"fixed-case\">PBS<\/jats:styled-content>, produced apatite\u2010like crystalline precipitates of significantly lower Ca\/P ratios.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12290","type":"journal-article","created":{"date-parts":[[2014,4,5]],"date-time":"2014-04-05T06:57:14Z","timestamp":1396681034000},"page":"124-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Evaluation of calcium\u2010releasing and apatite\u2010forming abilities of fast\u2010setting calcium silicate\u2010based endodontic materials"],"prefix":"10.1111","volume":"48","author":[{"given":"L.","family":"Han","sequence":"first","affiliation":[{"name":"Division of Cariology, Operative Dentistry and Endodontics Department of Oral Health Science Niigata University Graduate School of Medical and Dental Sciences Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kodama","sequence":"additional","affiliation":[{"name":"Division of Cariology, Operative Dentistry and Endodontics Department of Oral Health Science Niigata University Graduate School of Medical and Dental Sciences Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Okiji","sequence":"additional","affiliation":[{"name":"Division of Cariology, Operative Dentistry and Endodontics Department of Oral Health Science Niigata University Graduate School of Medical and Dental Sciences Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2011.05.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2010.04.008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.12.018"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2005.08.009"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2008.01435.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2011.04.011"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.11.023"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2006.11.018"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2005.01.019"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2003.12"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.07.039"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2010.01768.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2012.02013.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2011.01924.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12062"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.4012\/dmj.2009-133"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.06.007"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.02.002"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/an9709500583"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.08.035"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/sca.20295"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2004.08.001"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2005.08.006"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.01.017"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.06.030"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.4012\/dmj.2013-113"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.10.007"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cemconcomp.2010.02.003"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-14392010000400019"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2010.01745.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/464280"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2010.01770.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.02.011"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-8846(01)00714-1"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.DON.0000133155.04468.41"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.2138\/rmg.2012.74.6"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.07.009"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2007.07.008"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2007.09.013"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.09.010"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(06)80967-2"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cemconres.2004.04.011"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12167"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(97)00022-7"}],"container-title":["International Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiej.12290","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.12290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T21:49:36Z","timestamp":1696283376000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iej.12290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,14]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/iej.12290"],"URL":"https:\/\/doi.org\/10.1111\/iej.12290","archive":["Portico"],"relation":{},"ISSN":["0143-2885","1365-2591"],"issn-type":[{"value":"0143-2885","type":"print"},{"value":"1365-2591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,14]]},"assertion":[{"value":"2014-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-04-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}