{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:25:43Z","timestamp":1785417943646,"version":"3.56.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T00:00:00Z","timestamp":1400716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2009\/10438-8"],"award-info":[{"award-number":["2009\/10438-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the anaesthetic efficacy of inferior alveolar nerve blocks (IANB) with 1.8\u00a0mL of 2% lidocaine (LI) to a buccal infiltration (BI) with 1.8\u00a0mL of 4% articaine (AR), both with 1\u00a0:\u00a0100\u00a0000 epinephrine, in patients with symptomatic irreversible pulpits in a randomized controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Volunteers presenting at the Emergency Centre (<jats:styled-content style=\"fixed-case\">FOP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UNICAMP<\/jats:styled-content>) were randomly divided into two groups (30 for <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> and 20 for <jats:styled-content style=\"fixed-case\">LI<\/jats:styled-content>). Operator and patient were not blinded. Success was recorded when complete pain\u2010free treatment was achieved after a single injection (<jats:styled-content style=\"fixed-case\">IANB<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">BI<\/jats:styled-content>) or when one supplemental injection was needed for emergency endodontic procedures. Success rate of supplemental injection was evaluated between and within groups using Fisher's exact test and chi\u2010square test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A higher success rate (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.03\/Fisher's exact test) was observed with <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> (40%) than with <jats:styled-content style=\"fixed-case\">LI<\/jats:styled-content> (10%). No significant difference was found when a single injection plus one supplemental injection was compared between groups (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>1.0; <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>\u00a0=\u00a070%; <jats:styled-content style=\"fixed-case\">LI<\/jats:styled-content>\u00a0=\u00a080%). However, supplemental injection increased the anaesthetic success rates (<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>,<jats:italic> P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.04; <jats:styled-content style=\"fixed-case\">LI<\/jats:styled-content>,<jats:italic> P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0001) within groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Single anaesthesia techniques (<jats:styled-content style=\"fixed-case\">IANB<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">BI<\/jats:styled-content>) were not able to achieve pain\u2010free emergency endodontic treatment. Supplemental anaesthetic techniques should be considered prior to treatment procedures in order to increase success rate (consort: registration number \u2013 <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>01912755\/Fapesp: #2009\/10834\u20104).<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12293","type":"journal-article","created":{"date-parts":[[2014,4,5]],"date-time":"2014-04-05T13:54:41Z","timestamp":1396706081000},"page":"145-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["4% articaine buccal infiltration versus 2% lidocaine inferior alveolar nerve block for emergency root canal treatment in mandibular molars with irreversible pulpits: a randomized clinical study"],"prefix":"10.1111","volume":"48","author":[{"given":"M. R. F. 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