{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:33:25Z","timestamp":1789205605182,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T00:00:00Z","timestamp":1406764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81100744"],"award-info":[{"award-number":["81100744"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate IL\u201017 expression in human pulpitis and to study the effects of IL\u201017 on the secretion of the chemokines IL\u20106 and IL\u20108 and the related signalling pathways.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Samples of human dental pulp tissue were obtained from healthy controls and patients with pulpitis. Cytokine IL\u201017 messenger RNA (mRNA) expression in the pulp tissue was detected by real\u2010time polymerase chain reaction. In addition, human dental pulp fibroblasts (HDPFs) were stimulated with IL\u201017. Production of IL\u20106 and IL\u20108 was determined by reverse transcriptase\u2010polymerase chain reaction and enzyme\u2010linked immunosorbent assay. Aspects of the nuclear factor\u2010kappa B (NF\u2010\u03baB) and mitogen\u2010activated protein kinases (MAPKs) signalling pathways were examined by Western blot analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Increased levels of IL\u201017 mRNA were found in inflamed dental pulp tissue (pulpitis). Stimulation of dental pulp tissue with IL\u201017 induced the production of IL\u20106 and IL\u20108 in a dose\u2010dependent manner. In addition, IL\u201017 stimulation resulted in rapid activation of nuclear factor\u2010kappaB (NF\u2010\u03baB), phosphorylation of p38 MAPK, extracellular signal\u2010regulated kinase (ERK) and Jun N\u2010terminal kinase (JNK) in HDPFs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IL\u201017 may participate in pulp tissue inflammation through chemokine production and NF\u2010\u03baB and MAPKs signalling pathways.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12339","type":"journal-article","created":{"date-parts":[[2014,7,5]],"date-time":"2014-07-05T13:53:19Z","timestamp":1404568399000},"page":"505-511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["<scp>IL<\/scp>\u201017 stimulates the production of the inflammatory chemokines <scp>IL<\/scp>\u20106 and <scp>IL<\/scp>\u20108 in human dental pulp fibroblasts"],"prefix":"10.1111","volume":"48","author":[{"given":"H.","family":"Xiong","sequence":"first","affiliation":[{"name":"State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology 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