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Teeth were grouped into two categories:IERR<\/jats:styled-content>absent to mild (indexes \u22644) and moderate to severeIERR<\/jats:styled-content>(indexes >4). Genetic variations in theIL<\/jats:styled-content>1<\/jats:italic>gene cluster were tested for their effect on the occurrence and extension ofIERR<\/jats:styled-content>using theGEE<\/jats:styled-content>model (generalized estimation equation). Patient's age at the moment of injury, timing of pulpectomy, extra\u2010alveolar period and storage condition of the avulsed teeth was included as possible confounders.<\/jats:p><\/jats:sec>Results<\/jats:title>No association was found betweenSNP<\/jats:styled-content>sIL<\/jats:styled-content>1A<\/jats:italic>\u2010889C\/T,IL<\/jats:styled-content>1B<\/jats:italic>+3954C\/T (rs1143634) andIL<\/jats:styled-content>1RN<\/jats:styled-content><\/jats:italic>+2018C\/T (rs419598) andIERR<\/jats:styled-content>indexes. Timing of pulpectomy (OR<\/jats:styled-content>3.5IC<\/jats:styled-content>95% 2.0\u20136.2P<\/jats:italic>\u00a0<\u00a00.001) and patient's age at the moment of trauma (OR<\/jats:styled-content>0.29IC<\/jats:styled-content>95% 0.12\u20130.67P<\/jats:italic>\u00a0=\u00a00.004) significantly affected the risk of developing severeIERR<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>While timing of pulpectomy and patient's age at the moment of trauma were confirmed as important risk factors,SNP<\/jats:styled-content>s within theIL<\/jats:styled-content>1<\/jats:italic>gene cluster did not affect the susceptibility forIERR<\/jats:styled-content>after replantation of permanent teeth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12384","type":"journal-article","created":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T21:17:48Z","timestamp":1412025468000},"page":"878-887","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A study of the interleukin\u20101 gene cluster polymorphisms and inflammatory external root resorption in replanted permanent teeth"],"prefix":"10.1111","volume":"48","author":[{"given":"J. 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