{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T23:50:09Z","timestamp":1779321009757,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T00:00:00Z","timestamp":1417564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To report the successful clinical and radiographic outcome of a regenerative endodontic treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Summary<\/jats:title><jats:p>A 16\u2010year\u2010old male patient presented with a discoloured, maxillary left lateral incisor with a necrotic pulp. Radiographic examination revealed an incompletely developed root with an open apex. Under local anaesthesia and rubber dam isolation, an access cavity was prepared and the necrotic pulpal remnants were removed. The canal was disinfected without mechanical instrumentation with 5.25% Na<jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>l solution and dried with sterile paper points. A triple antibiotic (metronidazole, ciprofloxacin and minocycline) mixed with distilled water was packed in the canal and left for 28\u00a0days. Ten millimetres of whole blood was drawn by venipuncture from the patients antecubital vein for preparation of platelet\u2010rich plasma (<jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content>). After removal of the antibiotic mixture, the <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> was injected into the canal space up to the cementoenamel junction level. Three millimetres of white <jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content> was placed directly over the <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> clot. Two days later, the tooth was restored with permanent filling materials. The patient was recalled for 3, 6, 12, 24 and 36\u00a0months clinical\/radiographic follow\u2010up. A 3\u2010year follow\u2010up radiograph revealed resolution of the periapical lesion, increased thickening of the root walls, further root development and continued apical closure of the root apex. The tooth was not responsive to cold tests; however, sensitivity tests with an electric pulp tester (<jats:styled-content style=\"fixed-case\">EPT<\/jats:styled-content>) elicited a delayed positive response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key learning points<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Regeneration is a viable treatment modality that allows continued root development of immature teeth with open apices and necrotic pulps.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Platelet\u2010rich plasma appears to be a suitable scaffold for regeneration of vital tissues in teeth with a necrotic pulps and an associated periapical lesion.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Regenerative endodontic procedures may offer an effective treatment option to save teeth with compromised structural integrity.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12407","type":"journal-article","created":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T15:31:49Z","timestamp":1415115109000},"page":"902-910","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Regenerative endodontic treatment of an immature tooth with a necrotic pulp and apical periodontitis using platelet\u2010rich plasma (PRP) and mineral trioxide aggregate (MTA): a case report"],"prefix":"10.1111","volume":"48","author":[{"given":"G. 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