{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T15:11:00Z","timestamp":1775488260812,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T00:00:00Z","timestamp":1429142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To introduce a multimodular combination of techniques as a novel minimal invasive approach to investigate efficiently and accurately external cervical resorption (<jats:styled-content style=\"fixed-case\">ECR<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>One case of a central incisor with extensive external cervical resorption was selected to demonstrate the potential of a comparative novel study methodology. <jats:styled-content style=\"fixed-case\">ECR<\/jats:styled-content> diagnosis was based on clinical inspection, digital radiography and cone\u2010beam computed tomography (<jats:styled-content style=\"fixed-case\">CBCT<\/jats:styled-content>). After extraction, the tooth was investigated using microfocus computed tomography (micro\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>), nano\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> and hard tissue histology. These techniques were compared for their accuracy and applicability to highlight their advantages and disadvantages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nano\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> was more effective than micro\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CBCT<\/jats:styled-content> for detailed <jats:italic>ex vivo<\/jats:italic> exploration of <jats:styled-content style=\"fixed-case\">ECR<\/jats:styled-content>. The reparative tissue, pericanalar resorption resistant sheet (<jats:styled-content style=\"fixed-case\">PRRS<\/jats:styled-content>), pulp tissue reactions, resorption channels and their interconnection with the periodontal ligament space were accurately visualized by detailed processing and analysis of the nano\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> data set with Dataviewer and <jats:styled-content style=\"fixed-case\">CTA<\/jats:styled-content>n software. Nano\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> analysis provided better insight in the true extent of the resorption, based on quantitative measurements and 3D visualization of the tooth structure. Nano\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> imaging results were similar to hard tissue histology at the mineralized tissue level. To clarify the dynamic phenomenon of reparative tissue formation and substitution of the resorbed tissues, nano\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> needed to be associated with hard tissue histology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Nano\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> is a fast and minimal invasive technique for the <jats:italic>ex vivo<\/jats:italic> analysis and understanding of <jats:styled-content style=\"fixed-case\">ECR<\/jats:styled-content> and is complementary with hard tissue histology. A combined approach of clinical and <jats:styled-content style=\"fixed-case\">CBCT<\/jats:styled-content> examination, with nano\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> and histological mapping measurements, can provide an ideal platform for future <jats:styled-content style=\"fixed-case\">ECR<\/jats:styled-content> imaging and exploration studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12450","type":"journal-article","created":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T21:47:30Z","timestamp":1427406450000},"page":"287-300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["A novel multimodular methodology to investigate external cervical tooth resorption"],"prefix":"10.1111","volume":"49","author":[{"given":"A. M.","family":"Mavridou","sequence":"first","affiliation":[{"name":"Department of Oral Health Sciences BIOMAT Research Cluster KU Leuven &amp; University Hospital Leuven Leuven Belgium"},{"name":"Private practice, Endo Rotterdam Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Pyka","sequence":"additional","affiliation":[{"name":"Department of Materials Engineering (MTM) KU Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Kerckhofs","sequence":"additional","affiliation":[{"name":"Department of Materials Engineering (MTM) KU Leuven Leuven Belgium"},{"name":"Department of Development and Regeneration Skeletal Biology and Engineering Research Center Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Wevers","sequence":"additional","affiliation":[{"name":"Department of Materials Engineering (MTM) KU Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Bergmans","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences BIOMAT Research Cluster KU Leuven &amp; University Hospital Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Gunst","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences BIOMAT Research Cluster KU Leuven &amp; University Hospital Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Huybrechts","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences BIOMAT Research Cluster KU Leuven &amp; University Hospital Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Schepers","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences BIOMAT Research Cluster KU Leuven &amp; University Hospital Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Hauben","sequence":"additional","affiliation":[{"name":"Department of Imaging and Pathology KU Leuven &amp; University Hospital Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Lambrechts","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences BIOMAT Research Cluster KU Leuven &amp; University Hospital Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.290615.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12128"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.01895.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-010-9153-1"},{"key":"e_1_2_7_6_1","unstructured":"GarayA LegarretaJH MaciaI AzaRC(2012)Human tooth root canal geometry assessment through micro\u2010CT images. In: Hostens J ed. Proceedings of SkyScan User Meeting; pp. 10\u201016 Brussels Belgium. SkyScan User Meeting."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2010.01822.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12073"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-1546.2004.00060.x"},{"key":"e_1_2_7_10_1","unstructured":"KerckhofsG(2009)Morphological and mechanical quantification of porous structures by means of micro\u2010CT(Phd Thesis).Leuven Belgium:Catholic University of Leuven."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603513501175"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12088"},{"key":"e_1_2_7_13_1","first-page":"914","article-title":"Resorption pattern and radiographic diagnosis of invasive cervical resorption. A correlative microCT, scanning electron and light microscopic evaluation of a case series","volume":"122","author":"Luso S","year":"2012","journal-title":"Schweizer Monatsschrift f\u00fcr Zahnmedizin"},{"key":"e_1_2_7_14_1","first-page":"90","volume-title":"Human Oral Embryology and Histology","author":"Mj\u00f6r IA","year":"1986"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.50.487"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2007.01247.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.01.015"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12267"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/24\/1\/312"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-45456-4_19"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-006-0208-0"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.4248\/IJOS09031"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.04.238"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-64402012000500023"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.03.044"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2010.01830.x"}],"container-title":["International Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiej.12450","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.12450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T22:15:03Z","timestamp":1695507303000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iej.12450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,16]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/iej.12450"],"URL":"https:\/\/doi.org\/10.1111\/iej.12450","archive":["Portico"],"relation":{},"ISSN":["0143-2885","1365-2591"],"issn-type":[{"value":"0143-2885","type":"print"},{"value":"1365-2591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,16]]},"assertion":[{"value":"2014-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}