{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:09:52Z","timestamp":1790834992220,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T00:00:00Z","timestamp":1433980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2016,4]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>To evaluate whether the presence of apical periodontitis (AP<\/jats:styled-content>), root canal treatment (RCT<\/jats:styled-content>) and endodontic burden (EB<\/jats:styled-content>) \u2013 as the sum of AP<\/jats:styled-content> and RCT<\/jats:styled-content> sites \u2013 were associated with long\u2010term risk of incident cardiovascular events (CVE<\/jats:styled-content>), including cardiovascular\u2010related mortality, using data on participants in the Baltimore Longitudinal Study of Ageing (BLSA<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methodology<\/jats:title>This retrospective cohort included 278 dentate participants in the BLSA<\/jats:styled-content> with complete medical and dental examinations. Periodontal disease (PD<\/jats:styled-content>) and missing teeth were recorded. The total number of AP<\/jats:styled-content> and RCT<\/jats:styled-content> sites was determined from panoramic radiographs. EB<\/jats:styled-content> was calculated as the sum of AP<\/jats:styled-content> and RCT<\/jats:styled-content> sites. Oral inflammatory burden (OIB<\/jats:styled-content>) was calculated combining PD<\/jats:styled-content> and EB<\/jats:styled-content>. The main outcome was incident CVE<\/jats:styled-content> including angina, myocardial infarction and cardiovascular\u2010related death. Participants were monitored for up to 44\u00a0years (mean\u00a0=\u00a017.4\u00b1\u00a011.1\u00a0years) following dental examination. Relative risks (RR<\/jats:styled-content>s) were calculated through Poisson regression models, estimating the relationship between AP<\/jats:styled-content>, RCT<\/jats:styled-content>, EB<\/jats:styled-content>, PD<\/jats:styled-content>, OIB<\/jats:styled-content> and incident CVE<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Mean age at baseline was 55.0\u00a0\u00b116.8\u00a0years and 51.4% were men. Sixty\u2010two participants (22.3%) developed CVE<\/jats:styled-content>. Bivariate analysis showed that PD<\/jats:styled-content>, EB<\/jats:styled-content>, number of teeth and OIB<\/jats:styled-content> were associated with incident CVE<\/jats:styled-content>. Multivariate models, adjusted for socio\u2010demographic and medical variables, showed that age \u226560\u00a0years (RR<\/jats:styled-content>\u00a0=\u00a03.07, 95% CI<\/jats:styled-content>\u00a0=1.68\u20135.62), hypertension (RR<\/jats:styled-content>\u00a0=\u00a02.0, 95% CI<\/jats:styled-content>\u00a0=\u00a01.16\u20133.46) and EB<\/jats:styled-content> \u22653 (RR<\/jats:styled-content>\u00a0=\u00a01.77, 95% CI<\/jats:styled-content>\u00a0=\u00a01.04\u20133.02) were independently associated with incident CVE<\/jats:styled-content>. The association between OIB<\/jats:styled-content> and incident CVE<\/jats:styled-content> was reduced to nonsignificance after adjustments (RR<\/jats:styled-content>\u00a0=\u00a01.97, 95% CI<\/jats:styled-content>\u00a0=\u00a00.83\u20134.70).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>EB<\/jats:styled-content> in midlife was an independent predictor of CVE<\/jats:styled-content> amongst community\u2010dwelling participants in the BLSA<\/jats:styled-content>. Prospective studies are required to evaluate cardiovascular risk reduction with the treatment of AP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12468","type":"journal-article","created":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T13:23:06Z","timestamp":1432300986000},"page":"334-342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Apical periodontitis and incident cardiovascular events in the Baltimore Longitudinal Study of Ageing"],"prefix":"10.1111","volume":"49","author":[{"given":"M. S.","family":"Gomes","sequence":"first","affiliation":[{"name":"Medical and Dental Center of the Military Police of Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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