{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:22:00Z","timestamp":1740126120949,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T00:00:00Z","timestamp":1433980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the relationship between mononuclear inflammatory infiltrate and the expression of a proliferative immunomarker (Ki\u201067) as well as to evaluate basement membrane and extracellular matrix proteins (laminin and collagen type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>) in radicular cysts and dentigerous cysts (<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Immunohistochemical analyses were performed in heavily inflamed radicular cysts (<jats:styled-content style=\"fixed-case\">HIRC<\/jats:styled-content>), slightly inflamed radicular cysts (<jats:styled-content style=\"fixed-case\">SIRC<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a020) using Ki\u201067 (Dako<jats:sup>\u00ae<\/jats:sup>, 1\u00a0:\u00a050), anticollagen type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup>, 1\u00a0:\u00a040) and antilaminin (<jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup>, 1\u00a0:\u00a020). The data were analysed using <jats:sc>anova<\/jats:sc>\/Tukey's test (Ki\u201067) and Kruskal\u2013Wallis\/Dunn's test (collagen type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> and laminin) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The immunoexpression of Ki\u201067 was significantly greater in the <jats:styled-content style=\"fixed-case\">SIRC<\/jats:styled-content> group compared with the <jats:styled-content style=\"fixed-case\">HIRC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0040). Likewise, the immunoexpression of collagen type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> in the basement membrane of the <jats:styled-content style=\"fixed-case\">SIRC<\/jats:styled-content> group was significantly more continuous (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0475) than in the <jats:styled-content style=\"fixed-case\">HIRC<\/jats:styled-content> group. <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> had significantly less collagen type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> in extracellular matrix immunoexpression than <jats:styled-content style=\"fixed-case\">HIRC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SIRC<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0246). Laminin was absent in the basement membrane in the <jats:styled-content style=\"fixed-case\">SIRC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> groups, and the extracellular matrix of the <jats:styled-content style=\"fixed-case\">HIRC<\/jats:styled-content> was weak and punctate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence of inflammatory factors in the radicular cyst wall modified the expression of proliferation factors in the epithelial lining and the expression of collagen type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> and laminin in the basement membrane, but did not modify extracellular matrix behaviour in radicular cysts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12472","type":"journal-article","created":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T13:59:24Z","timestamp":1432303164000},"page":"447-453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Study of the relationship between mononuclear inflammatory infiltrate and Ki\u201067 and basement membrane and extracellular matrix protein expression in radicular cysts"],"prefix":"10.1111","volume":"49","author":[{"given":"R. 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