{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T23:43:04Z","timestamp":1793058184610,"version":"4.5.0"},"reference-count":146,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T00:00:00Z","timestamp":1438560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The prevalence of apical periodontitis (\n                    <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>\n                    ) in Europe has been reported to affect 61% of individuals and 14% of teeth, and increase with age. Likewise, the prevalence of root canal treatment (\n                    <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>\n                    ) in Europe is estimated to be around 30\u201350% of individuals and 2\u20139% of teeth with radiographic evidence of chronic persistent\n                    <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>\n                    in 30\u201365% of root filled teeth (\n                    <jats:styled-content style=\"fixed-case\">RFT<\/jats:styled-content>\n                    ).\n                    <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>\n                    is not only a local phenomenon and for some time the medical and dental scientific community have analysed the possible connection between apical periodontits and systemic health. Endodontic medicine has developed, with increasing numbers of reports describing the association between periapical inflammation and systemic diseases. The results of studies carried out both in animal models and humans are not conclusive, but suggest an association between endodontic variables, that is\n                    <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>\n                    , and diabetes mellitus (\n                    <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n                    ), tobacco smoking, coronary heart disease and other systemic diseases. Several studies have reported a higher prevalence of periapical lesions, delayed periapical repair, greater size of osteolityc lesions, greater likelihood of asymptomatic infections and poorer prognosis for\n                    <jats:styled-content style=\"fixed-case\">RFT<\/jats:styled-content>\n                    in diabetic patients. On the other hand, recent studies have found that a poorer periapical status correlates with higher HbA1c levels and poor glycaemic control in type 2 diabetic patients. However, there is no scientific evidence supporting a causal effect of periapical inflammation on diabetes metabolic control. The possible association between smoking habits and endodontic infection has also been investigated, with controversial results. The aim of this paper was to review the literature on the association between endodontic variables and systemic health (especially\n                    <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n                    and smoking habits).\n                  <\/jats:p>","DOI":"10.1111\/iej.12507","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T13:32:38Z","timestamp":1436880758000},"page":"933-951","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":281,"title":["Endodontic medicine: connections between apical periodontitis and systemic diseases"],"prefix":"10.1111","volume":"48","author":[{"given":"J. J.","family":"Segura\u2010Egea","sequence":"first","affiliation":[{"name":"Endodontic Section Department of Stomatology School of Dentistry University of Sevilla Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mart\u00edn\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Endodontic Section Department of Stomatology School of Dentistry University of Sevilla Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Castellanos\u2010Cosano","sequence":"additional","affiliation":[{"name":"Special Care Dentistry Section Department of Stomatology School of Dentistry University of Sevilla Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2000.107059"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1258\/rsmsmj.54.2.41"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.12.031"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2008.09.016"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr032"},{"issue":"10","key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1902\/jop.1996.67.10.1123","article-title":"Periodontal disease and cardiovascular disease","volume":"67","author":"Beck J","year":"1996","journal-title":"Journal of Periodontology"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200306000-00001"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(63)90226-3"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.8.1338"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2004.00112.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(03)00034-9"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.4.513"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1205847109"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-1546.2004.00087.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608501104"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12089"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.19148"},{"key":"e_1_2_5_19_1","first-page":"87","article-title":"The biology of the endodontic patient: 3. Variability in periapical healing and blood glucose","volume":"23","author":"Cheraskin E","year":"1968","journal-title":"Journal of Oral Medicine"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-012-0853-7"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12136"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-014-1192-7"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.01.034"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01498.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12506"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.02.013"},{"key":"e_1_2_5_27_1","volume-title":"Social Determinants of Health and Well\u2010Being among Young People","author":"Currie C","year":"2012"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199701)14:1<29::AID-DIA300>3.0.CO;2-V"},{"key":"e_1_2_5_29_1","first-page":"e287","article-title":"Prevalence of medically compromised conditions in dental patients","volume":"14","author":"Dhanuthai K","year":"2009","journal-title":"Medicina Oral, Patolog\u00eda Oral y Cirug\u00eda Bucal"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2010.0205"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.2004.00579.x"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2006.12.025"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110324"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2003.00640.x"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2006.01141.x"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2012.05.004"},{"key":"e_1_2_5_37_1","first-page":"179","volume-title":"Essential Endodontology. Prevention and Treatment of Apical Periodontitis","author":"Eriksen HM","year":"1998"},{"key":"e_1_2_5_38_1","volume-title":"The Tobacco Atlas","author":"Eriksen M","year":"2012"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaceta.2013.03.002"},{"issue":"1","key":"e_1_2_5_40_1","first-page":"S4","article-title":"Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus","volume":"23","author":"Expert Committee on the Diagnosis and Classification of Diabetes Mellitus","year":"2000","journal-title":"Diabetes Care"},{"key":"e_1_2_5_41_1","first-page":"198","article-title":"Number of teeth, prevalence of caries and periapical lesions in insulin\u2010dependent diabetics","volume":"97","author":"Falk H","year":"1989","journal-title":"Scandinavian Journal of Dental Research"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.20344\/amp.2089"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2002.130322"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2003.0016"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200201000-00003"},{"key":"e_1_2_5_46_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1177\/120347540400800603","article-title":"Cutaneous effects of smoking","volume":"8","author":"Freiman A","year":"2004","journal-title":"Journal of Cutaneous Medicine and Surgery"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350500469680"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-2358.2004.00025.x"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.09.010"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.10.032"},{"key":"e_1_2_5_51_1","first-page":"179","article-title":"The 2013 American Association of Clinical Endocrinologists\u2019 diabetes mellitus management recommendations: improvements needed","volume":"174","author":"Gionfriddo MR","year":"2014","journal-title":"Journal of the American Medical Association Internal Medicine"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000110789.20526.9D"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.2174\/15733998113099990066"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2560"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2010.02332.x"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2001.6.1.125"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308200416"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2003.107"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.8.1214"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/485082"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0143-2885.2004.00759.x"},{"key":"e_1_2_5_62_1","doi-asserted-by":"crossref","first-page":"e195","DOI":"10.1016\/j.joen.2007.12.008","article-title":"Relationship between systemic diseases and endodontics: an online study guide","volume":"34","author":"JOE Editorial Board","year":"2008","journal-title":"Journal of Endodontics"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-14-1296"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2012.00456.x"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.2.196"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2008.10.016"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028007710.x"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411000110030501"},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0528.2003.00032.x"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2007.01224.x"},{"key":"e_1_2_5_71_1","first-page":"53","article-title":"Diabetes enhances dental caries and apical periodontitis in caries\u2010susceptible WBN\/KobSlc rats","volume":"61","author":"Kodama Y","year":"2011","journal-title":"Comparative Medicine"},{"key":"e_1_2_5_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(96)80243-3"},{"key":"e_1_2_5_73_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1999.0029"},{"key":"e_1_2_5_74_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608500406"},{"key":"e_1_2_5_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1549-8719.2000.tb00135.x"},{"key":"e_1_2_5_76_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431X20143996"},{"key":"e_1_2_5_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12072"},{"key":"e_1_2_5_78_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1996.070405.x"},{"key":"e_1_2_5_79_1","first-page":"387","volume-title":"Dental Management of the Medically Compromised Patient","author":"Little JW","year":"1997"},{"key":"e_1_2_5_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.03.010"},{"key":"e_1_2_5_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.01.002"},{"key":"e_1_2_5_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875-595X.2011.00087.x"},{"key":"e_1_2_5_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.02.011"},{"key":"e_1_2_5_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/ger.12076"},{"key":"e_1_2_5_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph10094418"},{"key":"e_1_2_5_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.06.065"},{"key":"e_1_2_5_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00661.x"},{"key":"e_1_2_5_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.11.001"},{"key":"e_1_2_5_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-1546.2004.00095.x"},{"key":"e_1_2_5_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-1546.2004.00103.x"},{"key":"e_1_2_5_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266\u2010014\u20100165\u20102"},{"key":"e_1_2_5_92_1","first-page":"243","volume-title":"Carranza. Periodontolog\u00eda Cl\u00ednica","author":"Mealey B","year":"2004"},{"key":"e_1_2_5_93_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050459"},{"key":"e_1_2_5_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2006.03.007"},{"key":"e_1_2_5_95_1","first-page":"25","article-title":"Stress and the inflammatory process: a major cause of pancreatic cell death in type 2 diabetes","volume":"7","author":"Montane J","year":"2014","journal-title":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy"},{"key":"e_1_2_5_96_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.15.e808"},{"key":"e_1_2_5_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2006.01099.x"},{"key":"e_1_2_5_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12280"},{"key":"e_1_2_5_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2007.01323.x"},{"key":"e_1_2_5_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2011.01873.x"},{"key":"e_1_2_5_101_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.174029"},{"key":"e_1_2_5_102_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.46.11.1768"},{"key":"e_1_2_5_103_1","doi-asserted-by":"publisher","DOI":"10.1186\/1617-9625-11-13"},{"key":"e_1_2_5_104_1","first-page":"179","volume-title":"Essential Endodontology. Prevention and Treatment of Apical Periodontitis","author":"\u00d8rstavik D","year":"2007"},{"key":"e_1_2_5_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1986.tb00119.x"},{"key":"e_1_2_5_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.03.004"},{"key":"e_1_2_5_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00786.x"},{"key":"e_1_2_5_108_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.3.813"},{"key":"e_1_2_5_109_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/327417"},{"key":"e_1_2_5_110_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1988.59.5.318"},{"key":"e_1_2_5_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.10.006"},{"key":"e_1_2_5_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-012-0893-z"},{"key":"e_1_2_5_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00163.x"},{"key":"e_1_2_5_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01282.x"},{"key":"e_1_2_5_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.12.024"},{"key":"e_1_2_5_116_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.1.27"},{"key":"e_1_2_5_117_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.1.43"},{"key":"e_1_2_5_118_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2003.8.1.54"},{"key":"e_1_2_5_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2005.00996.x"},{"key":"e_1_2_5_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2007.01365.x"},{"key":"e_1_2_5_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2010.08.004"},{"key":"e_1_2_5_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.03.004"},{"key":"e_1_2_5_123_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.17452"},{"key":"e_1_2_5_124_1","first-page":"84","article-title":"Respuesta inmune pulpar frente a la caries: mecanismos de reconocimiento inespec\u00edfico de ant\u00edgenos bacterianos","volume":"31","author":"Segura\u2010Egea JJ","year":"2013","journal-title":"Endodoncia"},{"key":"e_1_2_5_125_1","first-page":"85","article-title":"Respuesta inmune innata pulpar frente a la caries: mecanismos efectores","volume":"32","author":"Segura\u2010Egea JJ","year":"2014","journal-title":"Endodoncia"},{"key":"e_1_2_5_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2009.472"},{"key":"e_1_2_5_127_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0528.2000.280310.x"},{"key":"e_1_2_5_128_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.140408"},{"key":"e_1_2_5_129_1","volume-title":"Treatment of Endodontic Infections","author":"Siqueira JF","year":"2011"},{"key":"e_1_2_5_130_1","doi-asserted-by":"publisher","DOI":"10.1111\/etp.12060"},{"key":"e_1_2_5_131_1","first-page":"263","article-title":"The relationship between periodontal diseases and diabetes: an overview","volume":"91","author":"Soskolne WA","year":"2001","journal-title":"Annals of Periodontology"},{"issue":"21","key":"e_1_2_5_132_1","first-page":"1","article-title":"The dependence of the results of pulp therapy on certain factors","volume":"14","author":"Strindberg LZ","year":"1956","journal-title":"Acta Odontologica Scandinavica"},{"key":"e_1_2_5_133_1","first-page":"242","volume-title":"Essential Endodontology","author":"Sundqvist G","year":"1998"},{"key":"e_1_2_5_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2011.07.010"},{"key":"e_1_2_5_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.07.126"},{"key":"e_1_2_5_136_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6979.2004.00460.x"},{"key":"e_1_2_5_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.07.002"},{"key":"e_1_2_5_138_1","first-page":"a35","article-title":"Impact of periodontitis on the diabetes\u2010related inflammatory status","volume":"76","author":"Tunes RS","year":"2010","journal-title":"Journal of the Canadian Dental Association"},{"key":"e_1_2_5_139_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1993.tb01051.x"},{"key":"e_1_2_5_140_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2012.02072.x"},{"key":"e_1_2_5_141_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2011.00417.x"},{"key":"e_1_2_5_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2010.08.054"},{"key":"e_1_2_5_143_1","doi-asserted-by":"publisher","DOI":"10.1922\/IDJ_2532Warnakulasuriya24"},{"key":"e_1_2_5_144_1","first-page":"588","article-title":"Daily tobacco smoking patterns in rural and urban areas of Poland \u2013 the results of the GATS study","volume":"20","author":"W\u0142odarczyk A","year":"2013","journal-title":"Annals of Agricultural and Environmental Medicine"},{"key":"e_1_2_5_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.12.030"},{"key":"e_1_2_5_146_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-5-13"},{"key":"e_1_2_5_147_1","first-page":"181","article-title":"Tobacco smoking in countries of the European Union","volume":"19","author":"Zato\u0144ski W","year":"2012","journal-title":"Annals of Agricultural and Environmental Medicine"}],"container-title":["International Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiej.12507","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.12507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:30:21Z","timestamp":1696339821000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iej.12507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,3]]},"references-count":146,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/iej.12507"],"URL":"https:\/\/doi.org\/10.1111\/iej.12507","archive":["Portico"],"relation":{},"ISSN":["0143-2885","1365-2591"],"issn-type":[{"value":"0143-2885","type":"print"},{"value":"1365-2591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,3]]},"assertion":[{"value":"2015-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}