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There was a history of a 6\u00a0months previous avulsion injury to the same tooth, which had been replanted after 20\u00a0min of extra\u2010oral time. On clinical examination, all teeth were asymptomatic and there was an arch wire splint placed on the mandibular incisors. Radiographic examination revealed severe inflammatory external root resorption of tooth 31. A diagnosis of necrotic pulp and asymptomatic apical periodontitis was made. Under local anaesthesia and rubber dam isolation, an access cavity was prepared. The canal was irrigated using 6% Na<jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>l solution delivered through the EndoVac negative pressure irrigation system (Endo Vac, Axis\/SybronEndo, Coppell, <jats:styled-content style=\"fixed-case\">TX<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> USA<\/jats:styled-content>). A 17% <jats:styled-content style=\"fixed-case\">EDTA<\/jats:styled-content> solution was used for 5\u00a0min followed by a final rinse of sterile water. The periapical tissues were probed using a K\u2010file, and bleeding was induced. A blood clot was allowed to form filling the entire canal. A thick plug of <jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content> was placed in direct contact with the blood clot. The tooth was restored with composite resin. All procedures were performed in a single visit. The splint was removed 2\u00a0weeks later. Recall examination after 24\u00a0months revealed healthy soft tissues with normal periodontal probing and mobility. The 24\u00a0months radiographic evaluation revealed healing of the severe inflammatory external root resorption and continuous root development\/dentine wall thickening of the apical third. No signs of ankylosis or significant discoloration was present.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12515","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T06:34:50Z","timestamp":1437546890000},"page":"802-812","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The use of a single\u2010step regenerative approach for the treatment of a replanted mandibular central incisor with severe resorption"],"prefix":"10.1111","volume":"49","author":[{"given":"A.","family":"Chaniotis","sequence":"first","affiliation":[{"name":"Private Practice Kalithea Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.09.019"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1995.1306"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2012.01125.x"},{"key":"e_1_2_7_5_1","first-page":"329","article-title":"Etiology and pathogenesis of traumatic dental injuries. 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