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All patients were submitted to radiographic, clinical and periodontal evaluation. Plasmatic levels of <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u20106 and fibrinogen were measured on the morning of the first periodontal appointment using commercially available kits. Multiple linear regression analyses were carried out to appraise the effect of the co\u2010variables on the plasmatic levels of the inflammatory markers assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 170 subjects who participated, 105 (61.8%) were females and the median age of the participants was 53\u00a0years (range: 40\u201378). The adjusted multiple linear analyses demonstrated that plasmatic levels of <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels were associated with the body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.259, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and residual tooth roots (<jats:styled-content style=\"fixed-case\">RTR<\/jats:styled-content>) (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.191, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.041). <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 and fibrinogen levels showed associated with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.400, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 and <jats:italic>r<\/jats:italic>\u00a0=\u00a00.214, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002 respectively). <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> correlated weakly with <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.250, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005), <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.174, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.020) and fibrinogen (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.393, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The null hypothesis was rejected in favour of the alternative hypothesis. In other words, the presence of chronic apical periodontitis was associated with higher plasmatic levels of <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u20106 and fibrinogen, in a population of severely hypertensive patients. However, the weak association between <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> and each dependent variable suggests a modest participation of endodontic infection on the plasmatic levels of biomarkers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12567","type":"journal-article","created":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T15:06:48Z","timestamp":1445699208000},"page":"1107-1115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Association between apical periodontitis lesions and plasmatic levels of C\u2010reactive protein, interleukin 6 and fibrinogen in hypertensive patients"],"prefix":"10.1111","volume":"49","author":[{"given":"F.","family":"Vidal","sequence":"first","affiliation":[{"name":"Faculty of Dentistry Est\u00e1cio de S\u00e1 University Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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