{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:32:53Z","timestamp":1790861573404,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T00:00:00Z","timestamp":1450828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This randomized controlled trial was conducted to evaluate the effect of foraminal enlargement during chemomechanical root canal preparation on postoperative pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Seventy mandibular first molars with asymptomatic pulp necrosis and chronic apical periodontitis were randomized into two groups \u2013 foraminal enlargement (<jats:styled-content style=\"fixed-case\">FE<\/jats:styled-content>) and conventional nonforaminal enlargement (<jats:styled-content style=\"fixed-case\">NFE<\/jats:styled-content>). Canals were prepared according to the respective protocols, and the teeth were restored temporarily. Postoperatively, the patients were prescribed ibuprofen 400\u00a0mg, to be taken if required. Pain experience and analgesic intake were recorded for 7\u00a0days following chemomechanical preparation. The data were analysed using Mann\u2013Whitney U\u2010test and chi\u2010square tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pain experience was higher with foraminal enlargement than when using a conventional technique. A significant difference was observed in postoperative pain during the first 4\u00a0days and the sixth day (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05), with greater pain in the <jats:styled-content style=\"fixed-case\">FE<\/jats:styled-content> as compared to the <jats:styled-content style=\"fixed-case\">NFE<\/jats:styled-content> group. There was no significant difference in prevalence of analgesic intake and number of doses between the experimental groups (<jats:italic>P\u00a0<\/jats:italic>&gt;<jats:italic>\u00a0<\/jats:italic>0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Enlargement of the apical foramen during root canal treatment increased the incidence and intensity of postoperative pain.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12583","type":"journal-article","created":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T15:22:39Z","timestamp":1447860159000},"page":"1116-1123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Pain following foraminal enlargement in mandibular molars with necrosis and apical periodontitis: A randomized controlled trial"],"prefix":"10.1111","volume":"49","author":[{"given":"H. 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