{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T13:53:32Z","timestamp":1776088412926,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,16]],"date-time":"2016-04-16T00:00:00Z","timestamp":1460764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2017,5]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>To analyse the immunoreactivity of IL<\/jats:styled-content>\u20101\u03b1, TNF<\/jats:styled-content>\u2010\u03b1 and IL<\/jats:styled-content>\u201010 in odontogenic cysts and tumours and to investigate possible associations with established biological behaviours of these different lesions.<\/jats:p><\/jats:sec>Methodology<\/jats:title>Immunohistochemical expression of anti\u2010IL<\/jats:styled-content>\u20101\u03b1, anti\u2010TNF<\/jats:styled-content>\u2010\u03b1 and anti\u2010IL<\/jats:styled-content>\u201010 antibodies was assessed on epithelium and mesenchyme of 20 radicular cysts (RC<\/jats:styled-content>s), 20 residual cysts (REC<\/jats:styled-content>s), 20 dentigerous cysts (DC<\/jats:styled-content>s), 18 solid ameloblastomas (SA<\/jats:styled-content>s), 20 keratocystic odontogenic tumours (KCOT<\/jats:styled-content>s) and 15 dental follicles (DF<\/jats:styled-content>s). Comparative analysis of data was performed using the nonparametric Wilcoxon signed\u2010rank test and Kruskal\u2013Wallis's test.<\/jats:p><\/jats:sec>Results<\/jats:title>Significantly greater expression of IL<\/jats:styled-content>\u20101\u03b1 in the epithelium was noted in RC<\/jats:styled-content>, KCOT<\/jats:styled-content> and SA<\/jats:styled-content> (P<\/jats:italic>\u00a0=\u00a00.01), whilst IL<\/jats:styled-content>\u201010 and TNF<\/jats:styled-content>\u2010\u03b1 was in the epithelium of RC<\/jats:styled-content>, DC<\/jats:styled-content> and KCOT<\/jats:styled-content> (P<\/jats:italic>\u00a0<\u00a00.01). In the mesenchyme, significantly greater immunopositivity was observed for IL<\/jats:styled-content>\u20101\u03b1, IL<\/jats:styled-content>\u201010 and TNF<\/jats:styled-content>\u2010\u03b1 in KCOT<\/jats:styled-content>, DC<\/jats:styled-content> and RC<\/jats:styled-content> (P<\/jats:italic>\u00a0<\u00a00.01). In epithelial and mesenchymal tissues, there were a significant number of cases of RC<\/jats:styled-content> and DC<\/jats:styled-content> with IL<\/jats:styled-content>\u20101\u03b1\u00a0<\u00a0IL<\/jats:styled-content>\u201010 ratio (P<\/jats:italic>\u00a0<\u00a00.01), whilst SA<\/jats:styled-content> and KCOT<\/jats:styled-content> showed IL<\/jats:styled-content>\u20101\u03b1\u00a0>\u00a0IL<\/jats:styled-content>\u201010 (P<\/jats:italic>\u00a0<\u00a00.01). There was a significantly greater percentage of DF<\/jats:styled-content>, DC<\/jats:styled-content> and KCOT<\/jats:styled-content> with TNF<\/jats:styled-content>\u2010\u03b1\u00a0>\u00a0IL<\/jats:styled-content>10 ratio (P<\/jats:italic>\u00a0<\u00a00.01).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>These results suggest involvement of the proteins in the pathogenesis of odontogenic cysts and tumours, with emphasis on the highest immunoreactivity of osteolysis stimulating factors in tumours with aggressive biological behaviour, such as SA<\/jats:styled-content> and KCOT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12640","type":"journal-article","created":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T07:22:50Z","timestamp":1458804170000},"page":"437-445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Immunoexpression of tumour necrosis factor\u2010\u03b1, interleukin\u20101\u03b1 and interleukin\u201010 on odontogenic cysts and tumours"],"prefix":"10.1111","volume":"50","author":[{"given":"M. C.","family":"S\u00e1","sequence":"first","affiliation":[{"name":"Faculty of Dentistry Department of Oral Pathology Federal University of Rio Grande do Norte Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. R.","family":"de Matos","sequence":"additional","affiliation":[{"name":"Department of Dentistry of Lagarto Federal University of Sergipe Lagarto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. S.","family":"Concei\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Department of Oral Pathology Federal University of Rio Grande do Norte Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. C. G. H.","family":"Leit\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Faculty of Dentistry Federal University of Bahia Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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