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Diabetes mellitus (<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>) was induced with alloxan. After <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> confirmation, all rats were anaesthetized and dental bleaching was performed with 35% hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>) on the right maxillary molars for 30\u00a0min. Left molars were used as controls. Bleaching resulted in four hemimaxillae groups: normoglycaemic (N), N\u2010bleached (<jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>le), diabetic (D) and D\u2010bleached (<jats:styled-content style=\"fixed-case\">DB<\/jats:styled-content>le). After 2 or 30\u00a0days, the animals were euthanized and the hemimaxillae were removed, processed for histopathological analysis and stained with haematoxylin\u2013eosin (<jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content>), Masson's trichrome (<jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>) and picrosirius red (<jats:styled-content style=\"fixed-case\">PSR<\/jats:styled-content>). Results obtained within animals (normoglycaemic or\u00a0diabetic rats) were submitted to Wilcoxon or paired <jats:italic>t<\/jats:italic>\u2010tests, and between animal (normoglycaemic and diabetic rats), to Mann\u2013Whitney test or <jats:italic>t<\/jats:italic>\u2010tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 2\u00a0days, the <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>le group had a mild inflammatory infiltration in the pulpal tissue, whilst the <jats:styled-content style=\"fixed-case\">DB<\/jats:styled-content>le had severe inflammation or necrosis (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). At 30\u00a0days, no inflammation was present. However, a significant difference in pulp chamber area reduction by reactionary dentine deposition was found between the <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>le and <jats:styled-content style=\"fixed-case\">DB<\/jats:styled-content>le groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). At 2\u00a0days, fewer immature collagen fibres and more mature collagen fibres were noted in the <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>le, D and <jats:styled-content style=\"fixed-case\">DB<\/jats:styled-content>le groups; this was significantly different when compared to the N group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). At 30\u00a0days, significantly fewer immature collagen fibres and more mature collagen fibres were noted in <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>le compared with <jats:styled-content style=\"fixed-case\">DB<\/jats:styled-content>le group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The inflammatory tissue response in rats\u2019 teeth after dental bleaching was greater in diabetic rats. Additionally, the increase in reactionary dentine deposition and mature collagen fibres observed in diabetic rats needs further evaluation to confirm the present results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12692","type":"journal-article","created":{"date-parts":[[2016,9,10]],"date-time":"2016-09-10T12:46:42Z","timestamp":1473511602000},"page":"790-798","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The effect of dental bleaching on pulpal tissue response in a diabetic animal model"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2348-7846","authenticated-orcid":false,"given":"L. T. A.","family":"Cintra","sequence":"first","affiliation":[{"name":"Departments of Endodontics Ara\u00e7atuba Dental School, Unesp \u2010 Univ Estadual Paulista Ara\u00e7atuba SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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