{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:33:23Z","timestamp":1789871603763,"version":"4.0.1"},"reference-count":65,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T00:00:00Z","timestamp":1476230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This randomized controlled trial compared the incidence of post\u2010instrumentation pain associated with Mtwo rotary NiTi files and the self\u2010adjusting file system following canal shaping and cleaning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Following sample size estimation, a total of 130 patients were randomized into two groups based on selection criteria [group Mtwo and group <jats:styled-content style=\"fixed-case\">SAF<\/jats:styled-content> (self\u2010adjusting file)]. Root canal treatment was carried out in two appointments. The teeth were endodontically treated with the appropriate allotted systems following the similar clinical parameters. Patients were asked to rate the intensity of pre\u2010instrumentation and post\u2010instrumentation pain (at 2, 4, 6, 8, 24, 48\u00a0h) using the <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> score. The Kruskal\u2013Wallis test was carried out for the overall comparisons of the two systems. The Friedman test was used to compare between time\u2010points with each system. Subgroup analyses for independent variables (gender, pulp status and diagnosis) used the Mann\u2013Whitney test and Wilcoxon signed ranks test (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant difference was found between the two groups with respect to post\u2010instrumentation pain. Teeth with pulpal necrosis had significant pain at 8\u00a0h compared with teeth with vital pulps (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). Teeth with vital pulps in the <jats:styled-content style=\"fixed-case\">SAF<\/jats:styled-content> group had significantly less post\u2010instrumentation pain compared with those in the Mtwo group at 6\u00a0h (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.042). Patients who had teeth with nonvital pulps in the <jats:styled-content style=\"fixed-case\">SAF<\/jats:styled-content> group experienced more post\u2010instrumentation pain at 8\u00a0h (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.017) and 24\u00a0h (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The incidence of post\u2010instrumentation pain at different time intervals in patients undergoing root canal treatment was similar for both the self\u2010adjusting file and Mtwo file systems.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12702","type":"journal-article","created":{"date-parts":[[2016,9,23]],"date-time":"2016-09-23T16:36:59Z","timestamp":1474648619000},"page":"750-760","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Post\u2010instrumentation pain after the use of either Mtwo or the <scp>SAF<\/scp> system: a randomized controlled clinical trial"],"prefix":"10.1111","volume":"50","author":[{"given":"P.","family":"Saumya\u2010Rajesh","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics Meenakshi Ammal Dental College and Hospital Meenakshi University Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Krithikadatta","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics Meenakshi Ammal Dental College and Hospital Meenakshi University Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Velmurugan","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics Meenakshi Ammal Dental College and Hospital Meenakshi University Chennai Tamil Nadu 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