{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:03:33Z","timestamp":1789589013302,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T00:00:00Z","timestamp":1488758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the effects of two different concentrations of NaOCl solution on postoperative pain following single\u2010visit root canal treatment in mandibular molars with irreversible pulpitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>A total of 122 patients who had mandibular molars with irreversible pulpitis were treated. The patients were randomly divided into two groups according to the concentration of NaOCl used during root canal instrumentation \u2013 either 2.5% or 5.25%. RaCe rotary instruments were used for root canal preparation, and all root canals were filled in one visit. Postoperative pain was evaluated using the visual analogue scale. Data were analysed by independent <jats:italic>t<\/jats:italic>\u2010test, chi\u2010square and Mann\u2013Whitney tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve patients were excluded for various reasons. Pain reported by 110 patients who were eligible to be included in the study was analysed. No significant differences were found in the age and gender of the patients between the two groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.50, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.51, respectively). The patients who had 5.25% NaOCl reported significantly lower postoperative pain compared to those who had 2.5% NaOCl during the first 72\u00a0h following treatment (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.021); however, there was no significant difference in pain felt by the patients during the rest of the study period, that is 4\u20137\u00a0days following treatment (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.185) when the four\u2010level pain categorization method was used. When the two\u2010level pain categorization method was used, the results revealed that patients who had 5.25% NaOCl reported significantly less pain for the first 3\u00a0days after treatment (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.026). The number of analgesics taken by patients who had 2.5% NaOCl was significantly higher than that taken by patients who had 5.25% NaOCl (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>5.25% NaOCl was associated with significantly lower postoperative pain compared to 2.5% NaOCl during the first 72\u00a0h following one\u2010visit root canal treatment of mandibular molars with irreversible pulpitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12749","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T14:03:04Z","timestamp":1485784984000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Effect of two different concentrations of sodium hypochlorite on postoperative pain following single\u2010visit root canal treatment: a triple\u2010blind randomized clinical trial"],"prefix":"10.1111","volume":"51","author":[{"given":"S.","family":"Farzaneh","sequence":"first","affiliation":[{"name":"Oral and Dental Diseases Research Center Kerman University of Medical Sciences Kerman  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Parirokh","sequence":"additional","affiliation":[{"name":"Endodontology Research Center Kerman University of Medical Sciences Kerman  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Nakhaee","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center Kerman University of Medical Sciences Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5727-4211","authenticated-orcid":false,"given":"P. 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