{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T20:58:47Z","timestamp":1773089927080,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T00:00:00Z","timestamp":1495670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the efficacy of 0.2\u00a0mL vs. 0.6\u00a0mL of 2% lidocaine when given as a supplementary intraligamentary injection after a failed inferior alveolar nerve block (IANB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Ninety\u2010seven adult patients with symptomatic irreversible pulpits received an <jats:styled-content style=\"fixed-case\">IANB<\/jats:styled-content> and root canal treatment was initiated. Pain during treatment was recorded using a visual analogue scale (Heft\u2010Parker <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>). Patients with unsuccessful anaesthesia (<jats:italic>n\u00a0<\/jats:italic>=\u00a078) randomly received intraligamentary injection of either 0.2\u00a0mL or 0.6\u00a0mL of 2% lidocaine with 1\u00a0:\u00a080\u00a0000 epinephrine. Root canal treatment was reinitiated. Success after primary injection or supplementary injection was defined as no or mild pain (<jats:styled-content style=\"fixed-case\">HP VAS<\/jats:styled-content> score \u226454\u00a0mm) during access preparation and root canal instrumentation. Heart rate was monitored using a finger pulse oximeter. The anaesthetic success rates were analysed with Pearson chi\u2010square test at 5% significance levels. The heart rate changes were analysed using <jats:italic>t<\/jats:italic>\u2010tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The intraligamentary injections with 0.2\u00a0mL solution gave an anaesthetic success rate of 64%, whilst the 0.6\u00a0mL was successful in 84% of cases with failed primary <jats:styled-content style=\"fixed-case\">IANB<\/jats:styled-content>. (\u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a04.3, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.03). There was no significant effect of the volume of intraligamentary injection on the change in heart rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increasing the volume of intraligamentary injection improved the success rates after a failed primary anaesthetic injection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12773","type":"journal-article","created":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T18:24:08Z","timestamp":1490725448000},"page":"5-11","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Does the volume of supplemental intraligamentary injections affect the anaesthetic success rate after a failed primary inferior alveolar nerve block? A randomized\u2010double blind clinical trial"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9792-4554","authenticated-orcid":false,"given":"V.","family":"Aggarwal","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry &amp; Endodontics Faculty of Dentistry Jamia Millia Islamia New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Singla","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry &amp; Endodontics SGT Dental College Gurgaon Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Miglani","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry &amp; Endodontics Faculty of Dentistry Jamia Millia Islamia New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kohli","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry &amp; Endodontics Faculty of Dentistry Jamia Millia Islamia New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry &amp; Endodontics SGT Dental College Gurgaon Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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