{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:51:50Z","timestamp":1787014310348,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"S3","license":[{"start":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T00:00:00Z","timestamp":1499126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This single\u2010centre randomized, double\u2010blind, placebo\u2010controlled clinical trial assessed the effect of a preoperative, single, oral dose of prednisolone on postoperative pain and postoperative analgesic intake in patients with symptomatic, irreversible pulpitis in mandibular molars.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      Four hundred participants, randomly assigned to two equal groups, received either 40\u00a0mg prednisolone or placebo tablets 30\u00a0min before single\u2010visit root canal treatment. Patients recorded their pain level 6, 12 and 24\u00a0h after treatment on a 100\u2010mm visual analogue scale. All patients received a sham capsule to take if needed as a postoperative analgesic, and, if the pain persisted, an analgesic was prescribed. The relative risk reduction and 95% confidence intervals (CI) were estimated for binary data. Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      \u2010test was used to compare postoperative pain intensity between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The relative risk reduction in pain incidence was 20.31% (95% CI: 12.03%, 27.82%) at 6\u00a0h, 23.39% (95% CI: 14.75%, 31.16%) at 12\u00a0h and 28.85% (95% CI: 18.08%, 38.20%) at 24\u00a0h. Prednisolone had significantly less post\u2010obturation pain intensity compared to placebo at 6, 12 and 24\u00a0h (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). The relative risk reduction in sham\u2010capsule intake was 54% (95% CI: 38%, 66%) and of analgesic intake was 55% (95% CI: 3%, 79%). No adverse effects were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Preoperative oral administration of a single dose of 40\u00a0mg prednisolone was beneficial to control short\u2010term post\u2010obturation pain after single\u2010visit root canal treatment in patients with symptomatic irreversible pulpitis reducing pain incidence after 24\u00a0h by approximately 30% and postoperative analgesic intake by approximately 55%.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.12795","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T01:22:48Z","timestamp":1496193768000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The effect of preoperative oral administration of prednisolone on postoperative pain in patients with symptomatic irreversible pulpitis: a single\u2010centre randomized controlled trial"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8343-6501","authenticated-orcid":false,"given":"A.","family":"Elkhadem","sequence":"first","affiliation":[{"name":"Centre for Evidence\u2010Based Dentistry Cairo University Cairo  Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ezzat","sequence":"additional","affiliation":[{"name":"Department of Endodontics Faculty of Oral and Dental Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ramadan","sequence":"additional","affiliation":[{"name":"Department of Endodontics Faculty of Oral and Dental Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"AbdelGhaffar","sequence":"additional","affiliation":[{"name":"Department of Endodontics Faculty of Oral and 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