{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:11:45Z","timestamp":1762542705566,"version":"3.37.3"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T00:00:00Z","timestamp":1499126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the association of clinical variables and polymorphisms (tag SNPs) in the interleukin 4 (<jats:italic>IL4<\/jats:italic>) gene, with the prognosis of avulsed and replanted teeth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Ninety\u2010four patients who suffered avulsion and had their teeth replanted and endodontically treated were included. Periapical radiographs were obtained soon after tooth replantation and after 1\u00a0year. For genotypic <jats:italic>IL4<\/jats:italic> gene analysis, the DNA from oral mucosa cells was collected, and polymorphisms were investigated by real\u2010time PCR. Univariate and multivariate analyses were performed to verify the association of clinical and genetic variables and the outcome of the replanted teeth (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After multivariate analysis, extra\u2010alveolar time longer than 1\u00a0h was significantly associated with external root resorption. No significant association was observed between <jats:italic>IL4<\/jats:italic> gene polymorphisms and root resorption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>No association between root resorption and <jats:italic>IL4<\/jats:italic> gene polymorphisms was observed. An extra\u2010alveolar time of more than 1\u00a0h was associated with a susceptibility for external root resorption. Replanting the tooth in its socket immediately is the most important factor to maintain a healthy root surface.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12797","type":"journal-article","created":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T22:29:59Z","timestamp":1497565799000},"page":"12-19","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Analysis of the association of clinical factors and <i>IL4<\/i> gene polymorphisms with root resorption in avulsed teeth after 1\u00a0year of replantation"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2331-0090","authenticated-orcid":false,"given":"L.","family":"Roskamp","sequence":"first","affiliation":[{"name":"School of Life Sciences Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1 Curitiba Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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