{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:36:20Z","timestamp":1759541780633,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T00:00:00Z","timestamp":1501459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["MAT2014\u201052036\u2010P"],"award-info":[{"award-number":["MAT2014\u201052036\u2010P"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the remineralization ability of two endodontic sealer cements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Mid\u2010coronal dentine surfaces were subjected to: (i) 37% phosphoric acid (<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>) or (ii) 0.5\u00a0mol L<jats:sup>\u22121<\/jats:sup> ethylenediaminetetraacetic acid (<jats:styled-content style=\"fixed-case\">EDTA<\/jats:styled-content>) conditioning prior to the application of two experimental hydroxyapatite\u2010based cements, containing sodium hydroxide (calcypatite) or zinc oxide oxiapatite respectively. Samples were stored in simulated body fluid for 24\u00a0h or 21\u00a0days. Remineralization of the dentine surfaces were studied by Raman spectroscopy (mapping with K\u2010means cluster and hierarchical cluster analysis) was undertaken. Nanoroughness and collagen fibril width measurements were performed with an atomic force microscopy. <jats:styled-content style=\"fixed-case\">ANOVA<\/jats:styled-content> and Student\u2013Newman\u2013Keuls test were performed (\u03b1=0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Phosphoric acid+oxiapatite promoted both the highest dentine mineralization (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and crystallographic maturity at the dentine surface. Noncrystalline amorphous\u2010like apatites were also formed. Dentine treated with <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>+calcypatite attained the roughest surface (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) with minimal fibril width (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Cross\u2010linking of collagen only became greater in the group <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>+oxiapatite after 21\u00a0days. The maximum relative mineral concentration and structure of collagen linked to the amide I and ratio amide <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AGE<\/jats:styled-content>s was obtained after using <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>+calcypatite at 21\u2010days time\u2010point (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). <jats:styled-content style=\"fixed-case\">EDTA<\/jats:styled-content> produced a lower stoichiometric hydroxyapatite (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) with decreased maturity, at the expense of carbonate band widening, although it favoured the nucleation of carbonated calcium phosphate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Dentine surfaces treated with <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>+oxiapatite attained the highest dentine remineralization with both crystalline\u2010stoichiometric and amorphous apatites, at 21\u00a0days. <jats:styled-content style=\"fixed-case\">EDTA<\/jats:styled-content> conditioning facilitated amorphous\u2010bulk mineral precipitation. The amorphization was more intense after using oxiapatite and provided an ion\u2010rich environment favouring <jats:italic>in\u00a0situ<\/jats:italic> dentine remineralization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12807","type":"journal-article","created":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T12:26:37Z","timestamp":1498566397000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A zinc oxide\u2010modified hydroxyapatite\u2010based cement facilitated new crystalline\u2010stoichiometric and amorphous apatite precipitation on dentine"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2172-7896","authenticated-orcid":false,"given":"M.","family":"Toledano","sequence":"first","affiliation":[{"name":"Department of Stomatology Dental Materials Section Faculty of Dentistry University of Granada Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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S.","family":"Aguilera","sequence":"additional","affiliation":[{"name":"Department of Stomatology Dental Materials Section Faculty of Dentistry University of Granada Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Osorio","sequence":"additional","affiliation":[{"name":"Department of Stomatology Dental Materials Section Faculty of Dentistry University of Granada Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Cabello","sequence":"additional","affiliation":[{"name":"Department of Stomatology Dental Materials Section Faculty of Dentistry University of Granada Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Toledano\u2010Osorio","sequence":"additional","affiliation":[{"name":"Department of Stomatology Dental Materials Section Faculty of Dentistry University of Granada Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Osorio","sequence":"additional","affiliation":[{"name":"Department of Stomatology Dental Materials Section Faculty of Dentistry University of Granada Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,31]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.1924668"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/876132"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2011.01049.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011271713758"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/sca.20199"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0an00459f"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2010.06.002"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-8477(02)00029-1"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.01.004"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2015.08.021"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0109-5641(00)00049-X"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.17.11.116012"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-9795(02)00143-7"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm201070g"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.2940337"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(94)90040-X"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000356873"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12518"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201200095"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(96)00796-X"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"9769","DOI":"10.1016\/S0021-9258(18)43459-X","article-title":"Properties of dissociatively extracted fetal tooth matrix proteins. 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