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Polyethylene tubes filled with<jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content>materials or empty tubes were implanted in dorsal connective tissue. On days 7 and 30, blood samples were collected for calcium, phosphorus and ALP measurement. The animals were euthanized; implanted tubes were removed and processed for immunohistochemical analysis of osteocalcin (<jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content>) and osteopontin (<jats:styled-content style=\"fixed-case\">OPN<\/jats:styled-content>). Kruskal\u2013Wallis followed by Dunn's multiple comparison test was performed for nonparametric data, and<jats:sc>anova<\/jats:sc>followed by Tukey's test for parametric data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No difference in systemic serum calcium levels between both groups was observed. On day 7, serum phosphorus levels within the<jats:styled-content style=\"fixed-case\">WMTA<\/jats:styled-content>healthy group were higher than that of the diabetic group. On day 30, healthy rats exhibited lower phosphorus levels than diabetic ones. At both time points, the diabetic group was associated with more ALP activity than the healthy group. Immunohistochemical analyses of the healthy group revealed<jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content>\u2010 and<jats:styled-content style=\"fixed-case\">OPN<\/jats:styled-content>\u2010positive cells in the presence of both MTA materials. However, under diabetic conditions, both<jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">OPN<\/jats:styled-content>were absent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both<jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content>materials were associated with an increase in serum calcium, phosphorus and<jats:styled-content style=\"fixed-case\">ALP<\/jats:styled-content>, suggesting a potential systemic effect, along with triggered differentiation of<jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content>\u2010 and<jats:styled-content style=\"fixed-case\">OPN<\/jats:styled-content>\u2010positive cells. Moreover, in diabetic conditions, an inhibitory effect on<jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content>\u2010induced differentiation of<jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content>\u2010 and<jats:styled-content style=\"fixed-case\">OPN<\/jats:styled-content>\u2010positive cells was detected.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12900","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T21:00:48Z","timestamp":1517259648000},"page":"889-900","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Systemic bone marker expression induced by grey and white mineral trioxide aggregate in normal and diabetic conditions"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8214-0880","authenticated-orcid":false,"given":"I. 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