{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:17:12Z","timestamp":1787498232885,"version":"build-2736575974"},"reference-count":65,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T00:00:00Z","timestamp":1520899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009042","name":"Universidad de Sevilla","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Regenerative endodontic procedures (\n                    <jats:styled-content style=\"fixed-case\">REP<\/jats:styled-content>\n                    s) are biologically based procedures planned to replace damaged tissues, including dentinee and root structures, as well as cells of the pulp\u2013dentine complex. Effective sterilization of the root canal is essential in\n                    <jats:styled-content style=\"fixed-case\">REP<\/jats:styled-content>\n                    s, and antibiotics have been widely used to disinfect root canals. The aim of this paper was to review the scientific literature on (i) Effectiveness of antibiotics used in\n                    <jats:styled-content style=\"fixed-case\">REP<\/jats:styled-content>\n                    s against bacteria implicated in endodontic disease; (ii) Scientific evidence supporting the use of topical antibiotics in\n                    <jats:styled-content style=\"fixed-case\">REP<\/jats:styled-content>\n                    s; (iii) Clinical implications of the use of antibiotics in\n                    <jats:styled-content style=\"fixed-case\">REP<\/jats:styled-content>\n                    s and the possible side effects; (iv) Effect of antibiotics on dental pulp stem cells; and (v) Ongoing research on the use of antibiotics in\n                    <jats:styled-content style=\"fixed-case\">REP<\/jats:styled-content>\n                    s. Antibiotics used in\n                    <jats:styled-content style=\"fixed-case\">REP<\/jats:styled-content>\n                    s are effective against bacteria implicated in endodontic infections. Triple antibiotic pastes with minocycline attain complete disinfection of immature teeth with necrotic pulps, without affecting\n                    <jats:styled-content style=\"fixed-case\">SCAP<\/jats:styled-content>\n                    . Experimental studies carried out in dogs support the use of antibiotics in\n                    <jats:styled-content style=\"fixed-case\">REP<\/jats:styled-content>\n                    s. Clinical studies report high success rates of\n                    <jats:styled-content style=\"fixed-case\">RET<\/jats:styled-content>\n                    using antibiotics as intracanal dressings. However, tooth discolouration is an important side effect of the use of\n                    <jats:styled-content style=\"fixed-case\">TAP<\/jats:styled-content>\n                    . An antibiotic paste containing only metronidazole and ciprofloxacin could be a good alternative to the use of\n                    <jats:styled-content style=\"fixed-case\">TAP<\/jats:styled-content>\n                    . The use of antibiotic\u2010containing scaffolds or clindamycin\u2010modified triple antibiotic (metronidazole, ciprofloxacin and clindamycin) polymer could be a biologically safe antimicrobial drug delivery system in\n                    <jats:styled-content style=\"fixed-case\">REP<\/jats:styled-content>\n                    s.\n                  <\/jats:p>","DOI":"10.1111\/iej.12913","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T10:53:43Z","timestamp":1519642423000},"page":"981-988","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Effectiveness and clinical implications of the use of topical antibiotics in regenerative endodontic procedures: a review"],"prefix":"10.1111","volume":"51","author":[{"given":"P.","family":"Montero\u2010Miralles","sequence":"first","affiliation":[{"name":"Endodontics Section Department of Stomatology School of Dentistry University of Sevilla Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mart\u00edn\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Endodontics Section Department of Stomatology School of Dentistry University of Sevilla Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Alonso\u2010Ezpeleta","sequence":"additional","affiliation":[{"name":"Endodontics Section Department of Stomatology School of Dentistry University of Zaragoza Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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