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A research protocol was developed and registered in <jats:styled-content style=\"fixed-case\">PROSPERO<\/jats:styled-content>. The systematic search was conducted during May 2017 in eight databases. The studies were selected based on inclusion and exclusion criteria. Two examiners analysed the sample independently, decided the eligibility for inclusion and classified the articles according to their quality. Statistical analysis was performed with Mantel\u2010Haenszel and I\u2010square (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>) tests considering a confidence interval of 95%. The initial sample consisted of 1130 articles, out of which four were eligible. The articles were published between 1993 and 2016. For both pulpal anaesthesia and pain control, there was no significant difference between mepivacaine and lidocaine (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.843, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00%, and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.183, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a021.1%, respectively). Mepivacaine and lidocaine were similarly effective for pulpal anaesthesia and pain control after inferior alveolar nerve blocks for root canal treatment.<\/jats:p>","DOI":"10.1111\/iej.12926","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T07:23:46Z","timestamp":1522049026000},"page":"1104-1117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Is mepivacaine as effective as lidocaine during inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis? 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