{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:19:05Z","timestamp":1789579145075,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T00:00:00Z","timestamp":1524441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate postoperative pain and radiographic evidence of periapical healing in teeth with apical periodontitis treated in one visit with an additional final\u00a0irrigation using 2% chlorhexidine (<jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content>) and to compare the results with conventional two\u2010visit root canal treatment (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>) with an intracanal calcium hydroxide (<jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content>) dressing as a control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Ninety asymptomatic maxillary anterior teeth with periapical lesions were treated by a single operator. Root canals were prepared using the step\u2010back technique with manual instrumentation with 2.5% Na<jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>l and 5% <jats:styled-content style=\"fixed-case\">EDTA<\/jats:styled-content> as irrigants. Half of the teeth were randomly assigned to the one\u2010visit (<jats:styled-content style=\"fixed-case\">OV<\/jats:styled-content>) group and received an additional final rinse with 2% <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content> before canal filling. The other teeth were treated in two visits (<jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content>) with a <jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content> paste made by mixing <jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content> powder and distilled water as an interappointment dressing. All patients were recalled and investigated clinically and radiographically for 24\u00a0months. Postoperative pain at 24\u201348\u00a0h and changes in apical bone\u00a0density indicating radiographic healing were evaluated statistically using the Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test followed by the Friedman and the Wilcoxon tests (\u03b1\u00a0<jats:italic>=\u00a0<\/jats:italic>0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences between two groups regarding the incidence of postoperative pain at 24\u00a0h (<jats:styled-content style=\"fixed-case\">OV<\/jats:styled-content> group 50% no pain, 47.6% mild, 2.4% moderate pain\/<jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content> group 55% no pain, 42.5% mild, 2.5% moderate pain) and at 48\u00a0h (<jats:styled-content style=\"fixed-case\">OV<\/jats:styled-content> group 95% no pain, 5% mild pain\/<jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content> group 98% no pain, 2% mild pain). None of the patients reported severe postoperative pain, swelling and\/or flare\u2010ups during the follow\u2010up period. There was no significant difference in the radiographic healing rates (<jats:styled-content style=\"fixed-case\">OV<\/jats:styled-content> group 97.6% <jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content> 1 and\/or <jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content> 2 and 2.4% <jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content> 3\/<jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content> group 95% <jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content> 1 and\/or <jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content> 2 and 5% <jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content> 3; <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both groups provided favourable and similar postoperative pain and periapical healing rates at 24\u00a0months. Thus, one\u2010visit <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content> with a final rinse with 2% <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content> is an acceptable alternative to two\u2010visit <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content> as temporary dressing in maxillary anterior teeth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12931","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T06:04:07Z","timestamp":1522476247000},"page":"1069-1076","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Efficacy of chlorhexidine as a final irrigant in one\u2010visit root canal treatment: a prospective comparative study"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7843-5686","authenticated-orcid":false,"given":"S.","family":"Mi\u00e7oo\u011fullar\u0131 Kurt","sequence":"first","affiliation":[{"name":"Department of Endodontology School of Dentistry Ege University Bornova \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6714-4282","authenticated-orcid":false,"given":"M. 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