{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T03:40:14Z","timestamp":1778211614902,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To test the hypothesis that polyacrylic acid\u2010based and calcium silicate materials are able to increase mineral density of artificially demineralized dentine produced by a microcosm model for caries formation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Forty\u2010five dentine cavities were prepared in nine sound human third molars (five in each tooth). Specimens received a bacterial inoculum and were incubated in <jats:styled-content style=\"fixed-case\">BHI<\/jats:styled-content> plus 5% of sucrose for 96\u00a0h to allow biofilm formation. After that, the specimens were scanned in a high energy micro\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> (baseline stack) and then, each cavity was filled with different cements: zinc polycarboxylate (Poly Zinc\u2122, Prevest DenPro, Jammu, India), conventional glass\u2013ionomer (Ketac Molar, 3M <jats:styled-content style=\"fixed-case\">ESPE<\/jats:styled-content>, Seefeld, Germany) and two calcium silicate\u2010based materials (<jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content>, Angelus, Londrina, Brazil and Biodentine\u2122, Septodont, Saint Maur des Fosses, France) whilst the central cavity was filled with utility wax (negative control). Specimens were kept for 45\u00a0days under simulated intrapulpal pressure using simulated body fluid and after, they were again scanned (treated stacks). Reconstruction of the acquired projections was accomplished using standardized parameters, and the percentage mineral density change was calculated around each cavity. Data were tested for normality using the Shapiro\u2013Wilk test, followed by nonparametric methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A microcosm artificial caries model was able to cause dentine demineralization (\u00b190% related to sound dentine). Significant increases in dentine mineral density were achieved using <jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content> or Poly Zinc\u2122 (43.56% and 41.64% remineralization), followed by Biodentine\u2122 (36.40%) and Ketac Molar (32.54%), <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>All cements increased mineral density in demineralized dentine, but zinc polycarboxylate cement and <jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content> had greater bioactive potential. Micro\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> proved to be an effective method to evaluate changes in mineral density within dentine in contact with bioactive materials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12941","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T07:00:44Z","timestamp":1524466844000},"page":"1292-1300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Mineral density in carious dentine after treatment with calcium silicates and polyacrylic acid\u2010based cements"],"prefix":"10.1111","volume":"51","author":[{"given":"P. M.","family":"Pires","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry and Orthodontics Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. P.","family":"Santos","sequence":"additional","affiliation":[{"name":"Laboratory for Nuclear Instrumentation Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Fonseca\u2010Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry and Orthodontics Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M.","family":"Pithon","sequence":"additional","affiliation":[{"name":"State University of Southwestern Bahia Jequi\u00e9 BA Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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