{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T06:59:40Z","timestamp":1776754780424,"version":"3.51.2"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T00:00:00Z","timestamp":1528675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the influence of different apical enlargement protocols on the radiographic and histological healing of apical periodontitis in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Apical periodontitis was induced bilaterally in the mandibular right and left first molars of 24 Wistar rats by pulp exposure to the oral cavity for 3\u00a0weeks. A standard serial root canal preparation technique was performed in the molar of one side, whilst the opposite side was the control group. Rats were randomly divided into three experimental groups (<jats:italic>n<\/jats:italic>\u00a0=\u00a08), according to the diameter of apical enlargement during root canal preparation: K\u2010files size 20 (<jats:styled-content style=\"fixed-case\">EG<\/jats:styled-content>1), size 25 (<jats:styled-content style=\"fixed-case\">EG<\/jats:styled-content>2) and size 30 (<jats:styled-content style=\"fixed-case\">EG<\/jats:styled-content>3). Each animal was its own positive control, because the opposite arch remained untreated. Root canals were filled with a standard technique. After 3\u00a0weeks, the animals were euthanized. The main outcome of apical periodontitis healing was evaluated radiographically (mm<jats:sup>2<\/jats:sup>) and histologically (ordinal scores of inflammation) using a <jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content> staining technique. The measurement of effect was obtained between the three experimental groups by carrying out generalized estimating equations, with Poisson regression with robust variance, pairing each experimental group with its respective control group within animals, adjusted for the mean within animal differences, with \u03b1\u00a0=\u00a05%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean and standard deviations of radiographic apical periodontitis size (mm<jats:sup>2<\/jats:sup>) and intensity of histological inflammatory scores were, respectively: <jats:styled-content style=\"fixed-case\">EG<\/jats:styled-content>1 (0.44\u00a0\u00b1\u00a00.27; 2.25\u00a0\u00b1\u00a00.46), <jats:styled-content style=\"fixed-case\">EG<\/jats:styled-content>2 (0.33\u00a0\u00b1\u00a00.10; 2.50\u00a0\u00b1\u00a00.53) and <jats:styled-content style=\"fixed-case\">EG<\/jats:styled-content>3 (0.22\u00a0\u00b1\u00a00.08; 2.63\u00a0\u00b1\u00a00.74). After 3 weeks, a significantly more favourable radiographic repair was observed when larger apical enlargement was performed (<jats:styled-content style=\"fixed-case\">EG<\/jats:styled-content>3), compared to <jats:styled-content style=\"fixed-case\">EG<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">EG<\/jats:styled-content>2 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). All experimental groups were associated with a significant difference on the radiographic and histological healing of apical periodontitis compared with its respective control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Under the experimental conditions of this study, a larger apical enlargement protocol favoured a more rapid radiographic repair of apical periodontitis in rats after a 3\u2010week follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.12949","type":"journal-article","created":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T11:34:17Z","timestamp":1525779257000},"page":"1261-1270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Influence of apical enlargement on the repair of apical periodontitis in rats"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7345-1529","authenticated-orcid":false,"given":"C. M.","family":"Jara","sequence":"first","affiliation":[{"name":"Pontifical Catholic University of Rio Grande do Sul \u2010 Porto Alegre Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3087-6922","authenticated-orcid":false,"given":"R. C.","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Pontifical Catholic University of Rio Grande do Sul \u2010 Porto Alegre Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6158-8384","authenticated-orcid":false,"given":"D. E.","family":"B\u00f6ttcher","sequence":"additional","affiliation":[{"name":"Pontifical Catholic University of Rio Grande do Sul \u2010 Porto Alegre Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. S.","family":"Souza","sequence":"additional","affiliation":[{"name":"Pontifical Catholic University of Rio Grande do Sul \u2010 Porto Alegre Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0394-5400","authenticated-orcid":false,"given":"M. S.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Pontifical Catholic University of Rio Grande do Sul \u2010 Porto Alegre Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A. P.","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Pontifical Catholic University of Rio Grande do Sul \u2010 Porto Alegre Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2010.12.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200406000-00012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2002.01019.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.10.012"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200211000-00008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/00140136708930910"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2007.11.023"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2010.01724.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1678-77572007000500011"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2010.03.001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-1546.2002.10102.x"},{"key":"e_1_2_7_13_1","first-page":"180","volume-title":"Endodontics","author":"Ingle JI","year":"1994"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(65)90166-0"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(77)80206-9"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.07.027"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.09.003"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1678-77572012000600012"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2006.08.004"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2004.00889.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.5037\/jomr.2014.5204"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10024-1376"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2007.01270.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2002.126164"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.06.024"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.05.014"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-8532(22)00677-2"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(71)90304-5"},{"key":"e_1_2_7_29_1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1055\/s-0039-1698976","article-title":"Apical third enlargement of the root canal and its relationship with the repair of periapical lesions","volume":"6","author":"Souza RA","year":"2012","journal-title":"European Journal Dentistry"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(94)90044-2"},{"key":"e_1_2_7_31_1","first-page":"129","article-title":"Changes in root canal microbiota during the development of rat periapical lesions","volume":"9","author":"Tani\u2010Ishii N","year":"1994","journal-title":"Molecular Oral Microbiology"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(76)80045-3"},{"key":"e_1_2_7_33_1","volume-title":"Endodontic Therapy","author":"Weine FS","year":"1996"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2000.106344"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(06)80067-1"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-03628-6"}],"container-title":["International Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiej.12949","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.12949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T01:54:07Z","timestamp":1694915647000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iej.12949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,11]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/iej.12949"],"URL":"https:\/\/doi.org\/10.1111\/iej.12949","archive":["Portico"],"relation":{},"ISSN":["0143-2885","1365-2591"],"issn-type":[{"value":"0143-2885","type":"print"},{"value":"1365-2591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,11]]},"assertion":[{"value":"2017-08-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}