{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:32:04Z","timestamp":1790620324451,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004621","name":"Kerman University of Medical Sciences","doi-asserted-by":"publisher","award":["IR.KMU.REC.1396.1087"],"award-info":[{"award-number":["IR.KMU.REC.1396.1087"]}],"id":[{"id":"10.13039\/501100004621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To assess the effects of central administration of \u03b1\u2010pinene alone and in combination with either bicuculline or naloxone, as\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:bold>GABA<\/jats:bold>\n                      <\/jats:styled-content>\n                      <jats:sub>A<\/jats:sub>\n                      and \u03bc\u2010opioid receptor antagonists, respectively, on capsaicin\u2010induced dental pulp stimulation in rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      Forty\u2010eight adult male Wistar rats aged 2\u00a0months (230\u2013270\u00a0g) were cannulated via their lateral ventricles for the central administration of the drugs. \u03b1\u2010Pinene was injected at 0.1, 0.2 and 0.4\u00a0\u03bcmol\u00a0L\n                      <jats:sup>\u22121<\/jats:sup>\n                      . Then, dental pulp stimulation was induced by intradental application of capsaicin solution (100\u00a0\u03bcg), and nociceptive scores were recorded for up to 40\u00a0min. For investigation of the anti\u2010inflammatory effects of \u03b1\u2010pinene, expression of\n                      <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\n                      \u20102 in the subnucleolus caudalis (Vc) of rats was determined using immunofluorescence staining. Nonparametric repeated measure Friedman and Kruskal\u2013Wallis tests as well as parametric one\u2010way analysis of variance were used for the statistical analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      \u03b1\u2010Pinene at 0.2 and 0.4\u00a0\u03bcmol\u00a0L\n                      <jats:sup>\u22121<\/jats:sup>\n                      was able to decrease capsaicin\u2010induced nociception. Moreover, there was a significant increase in the expression of\n                      <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\n                      \u20102\u2010positive cells in the Vc of capsaicin\u2010treated rats (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). This effect was prohibited by \u03b1\u2010pinene (0.4\u00a0\u03bcmol\u00a0L\n                      <jats:sup>\u22121<\/jats:sup>\n                      ). Co\u2010administration of bicuculline (1\u00a0\u03bcg per rat) or naloxone (6\u00a0\u03bcg per rat) with \u03b1\u2010pinene (0.4\u00a0\u03bcmol\u00a0L\n                      <jats:sup>\u22121<\/jats:sup>\n                      ), however, prevented the inhibitory effects of \u03b1\u2010pinene on both capsaicin\u2010induced pulp nociception and\n                      <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\n                      \u20102 over\u2010expression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Pinene exhibited significant curable effects on capsaicin\u2010induced pulpal nociception and inflammation mainly via pharmacological interfacing with\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:bold>GABA<\/jats:bold>\n                      <\/jats:styled-content>\n                      <jats:sub>A<\/jats:sub>\n                      and \u03bc\u2010opioid receptors.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.13006","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T00:18:52Z","timestamp":1535588332000},"page":"307-317","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The effect of central administration of alpha\u2010pinene on capsaicin\u2010induced dental pulp nociception"],"prefix":"10.1111","volume":"52","author":[{"given":"I.","family":"Rahbar","sequence":"first","affiliation":[{"name":"Department of Biology Faculty of Sciences Shahid Bahonar University of Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Abbasnejad","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Sciences Shahid Bahonar University 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